Signaling pathways and therapeutic interventions in gastric cancer
Gastric cancer (GC) ranks fifth in global cancer diagnosis and fourth in cancer-related death.
Despite tremendous progress in diagnosis and therapeutic strategies and significant …
Despite tremendous progress in diagnosis and therapeutic strategies and significant …
PI3K/AKT/mTOR signaling in gastric cancer: Epigenetics and beyond
S Fattahi, F Amjadi-Moheb, R Tabaripour, GH Ashrafi… - Life Sciences, 2020 - Elsevier
Abstract PI3K/AKT/mTOR pathway is one of the most important signaling pathways involved
in normal cellular processes. Its aberrant activation modulates autophagy, epithelial …
in normal cellular processes. Its aberrant activation modulates autophagy, epithelial …
The functions and regulation of the PTEN tumour suppressor: new modes and prospects
PTEN is a potent tumour suppressor, and its loss of function is frequently observed in both
heritable and sporadic cancers. PTEN has phosphatase-dependent and phosphatase …
heritable and sporadic cancers. PTEN has phosphatase-dependent and phosphatase …
The relation between PI3K/AKT signalling pathway and cancer
Abstract Phosphatidylinositol 3-kinases (PI3Ks) are crucial coordinators of intracellular
signalling in response to the extracellular stimulators. Hyperactivation of PI3K signalling …
signalling in response to the extracellular stimulators. Hyperactivation of PI3K signalling …
Epigenetic plasticity and the hallmarks of cancer
WA Flavahan, E Gaskell, BE Bernstein - Science, 2017 - science.org
BACKGROUND Chromatin is the essential medium through which transcription factors,
signaling pathways, and other cues alter gene activity and cellular phenotypes. It assumes …
signaling pathways, and other cues alter gene activity and cellular phenotypes. It assumes …
Epidermal growth factor receptor cell proliferation signaling pathways
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is commonly
upregulated in cancers such as in non-small-cell lung cancer, metastatic colorectal cancer …
upregulated in cancers such as in non-small-cell lung cancer, metastatic colorectal cancer …
Clinical implications of PTEN loss in prostate cancer
T Jamaspishvili, DM Berman, AE Ross, HI Scher… - Nature Reviews …, 2018 - nature.com
Genomic aberrations of the PTEN tumour suppressor gene are among the most common in
prostate cancer. Inactivation of PTEN by deletion or mutation is identified in∼ 20% of …
prostate cancer. Inactivation of PTEN by deletion or mutation is identified in∼ 20% of …
Regulating tumor suppressor genes: post-translational modifications
L Chen, S Liu, Y Tao - Signal transduction and targeted therapy, 2020 - nature.com
Tumor suppressor genes cooperate with each other in tumors. Three important tumor
suppressor proteins, retinoblastoma (Rb), p53, phosphatase, and tensin homolog deleted …
suppressor proteins, retinoblastoma (Rb), p53, phosphatase, and tensin homolog deleted …
The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy
Hypoxia is a non-physiological level of oxygen tension, a phenomenon common in a
majority of malignant tumors. Tumor-hypoxia leads to advanced but dysfunctional …
majority of malignant tumors. Tumor-hypoxia leads to advanced but dysfunctional …
Epidemiology of prostate cancer in Asian countries
T Kimura, S Egawa - International journal of urology, 2018 - Wiley Online Library
The incidence of prostate cancer has been increasing worldwide in recent years. The
GLOBOCAN project showed that prostate cancer was the second most frequently diagnosed …
GLOBOCAN project showed that prostate cancer was the second most frequently diagnosed …