[HTML][HTML] Prostate cancer review: genetics, diagnosis, treatment options, and alternative approaches
M Sekhoacha, K Riet, P Motloung, L Gumenku… - Molecules, 2022 - mdpi.com
Simple Summary Prostate cancer affects men of all racial and ethnic groups and leads to
higher rates of mortality in those belonging to a lower socioeconomic status due to late …
higher rates of mortality in those belonging to a lower socioeconomic status due to late …
Genetics and biology of prostate cancer
Despite the high long-term survival in localized prostate cancer, metastatic prostate cancer
remains largely incurable even after intensive multimodal therapy. The lethality of advanced …
remains largely incurable even after intensive multimodal therapy. The lethality of advanced …
[HTML][HTML] Targeting androgen receptor phase separation to overcome antiandrogen resistance
Patients with castration-resistant prostate cancer inevitably acquire resistance to
antiandrogen therapies in part because of androgen receptor (AR) mutations or splice …
antiandrogen therapies in part because of androgen receptor (AR) mutations or splice …
[HTML][HTML] A genomic and epigenomic atlas of prostate cancer in Asian populations
J Li, C Xu, HJ Lee, S Ren, X Zi, Z Zhang, H Wang, Y Yu… - Nature, 2020 - nature.com
Prostate cancer is the second most common cancer in men worldwide. Over the past
decade, large-scale integrative genomics efforts have enhanced our understanding of this …
decade, large-scale integrative genomics efforts have enhanced our understanding of this …
[HTML][HTML] Single-cell analysis of human primary prostate cancer reveals the heterogeneity of tumor-associated epithelial cell states
H Song, HNW Weinstein, P Allegakoen… - Nature …, 2022 - nature.com
Prostate cancer is the second most common malignancy in men worldwide and consists of a
mixture of tumor and non-tumor cell types. To characterize the prostate cancer tumor …
mixture of tumor and non-tumor cell types. To characterize the prostate cancer tumor …
Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer
Metabolism alterations are hallmarks of cancer, but the involvement of lipid metabolism in
disease progression is unclear. We investigated the role of lipid metabolism in prostate …
disease progression is unclear. We investigated the role of lipid metabolism in prostate …
[HTML][HTML] Identification of multipotent luminal progenitor cells in human prostate organoid cultures
WR Karthaus, PJ Iaquinta, J Drost, A Gracanin… - Cell, 2014 - cell.com
The prostate gland consists of basal and luminal cells arranged as pseudostratified
epithelium. In tissue recombination models, only basal cells reconstitute a complete prostate …
epithelium. In tissue recombination models, only basal cells reconstitute a complete prostate …
[HTML][HTML] SETD2 restricts prostate cancer metastasis by integrating EZH2 and AMPK signaling pathways
H Yuan, Y Han, X Wang, N Li, Q Liu, Y Yin, H Wang… - Cancer cell, 2020 - cell.com
The level of SETD2-mediated H3K36me3 is inversely correlated with that of EZH2-catalyzed
H3K27me3. Nevertheless, it remains unclear whether these two enzymatic activities are …
H3K27me3. Nevertheless, it remains unclear whether these two enzymatic activities are …
[HTML][HTML] Punctuated evolution of prostate cancer genomes
The analysis of exonic DNA from prostate cancers has identified recurrently mutated genes,
but the spectrum of genome-wide alterations has not been profiled extensively in this …
but the spectrum of genome-wide alterations has not been profiled extensively in this …
[HTML][HTML] A cellular anatomy of the normal adult human prostate and prostatic urethra
A comprehensive cellular anatomy of normal human prostate is essential for solving the
cellular origins of benign prostatic hyperplasia and prostate cancer. The tools used to …
cellular origins of benign prostatic hyperplasia and prostate cancer. The tools used to …