Ion channels and transporters mediate the transport of charged ions across hydrophobic
lipid membranes. In immune cells, divalent cations such as calcium, magnesium, and zinc …

Activated phosphoinositide 3-kinase delta syndrome (APDS) is a novel primary
immunodeficiency (PID) caused by heterozygous gain of function mutations in PI3Kδ …

The magnesium transporter 1 (MAGT1) is a critical regulator of basal intracellular free
magnesium (Mg2+) concentrations. Individuals with genetic deficiencies in MAGT1 have …

Haemophagocytic lymphohistiocytosis (HLH) is a life threatening complication of E pstein–B
arr virus (EBV) infection. The anti‐CD 20 antibody rituximab depletes B cells, leading to …

Epstein-Barr virus (EBV) is an oncogenic gammaherpesvirus that infects and persists in 95%
of adults worldwide and has the potential to cause fatal disease, especially lymphoma, in …

Background Primary immunodeficiency disorders (PID) are a group of heterogeneous
disorders mainly characterized by severe and recurrent infections and increased …

In this review, we focus on B-cell lymphoproliferative disorders (LPDs) and lymphomas
associated with Epstein–Barr virus (EBV). In some of these diseases—such as EBV-positive …

Background: Common variable immunodeficiency (CVID) is the most common clinically
significant primary immunodeficiency (PID) disorder characterized by variable clinical …

Purpose Patients with primary immunodeficiency diseases (PIDD) may present with
recurrent infections affecting different organs, organ-specific inflammation/autoimmunity, and …

Primary immunodeficiencies and immune dysregulatory disorders (PIDDs; now referred to
as inborn errors in immunity) are rare disorders with a prevalence of 41. 4 or 50.5 per …