Classically, the central nervous system (CNS) and the immune system are thought to
operate independently of each other. This simplistic view has been corrected in recent …

Chemokines and chemokine receptors are widely expressed by cells of the immune and
nervous systems. This review focuses on our current knowledge concerning the role of …

While neuroimmune interactions are increasingly recognized as important in nociceptive
processing, the nature and functional significance of these interactions is not well defined …

Intractable neuropathic pain is a frequent consequence of nerve injury or disease. When
peripheral nerves are injured, damaged axons undergo Wallerian degeneration. Schwann …

The development of new therapeutic approaches to the treatment of painful neuropathies
requires a better understanding of the mechanisms that underlie the development of these …

Development of analgesic tolerance and withdrawal-induced pain enhancement present
serious difficulties for the use of opioids for pain control. Although neuronal mechanisms to …

The activation of spinal cord glial cells has been implicated in the development of
neuropathic pain upon peripheral nerve injury. The molecular mechanisms underlying glial …

In contrast to physiological pain, pathological pain is not dependent on the presence of
tissue‐damaging stimuli. One type of pathological pain—neuropathic pain—is often a …

Chronic (neuropathic) pain is one of the most widespread and intractable of human
complaints, as well as being one of the most difficult syndromes to treat successfully with …

Synaptic plasticity is thought to be initiated by neurons only, with the prevailing view
assigning glial cells mere specify supportive functions for synaptic transmission and …