Neuropathic pain is generally defined as a chronic pain state resulting from peripheral
and/or central nerve injury. Effective treatment for neuropathic pain is still lacking, due in part …

Evidence indicates that central glial activation depends on nerve inputs from the site of injury
and release of chemical mediators. Hematogenous immune cells may migrate to/infiltrate …

Spinal cord injury (SCI) impairs sensory systems causing chronic allodynia. Mechanisms
underlying neuropathic pain have been more extensively studied following peripheral nerve …

It has previously been observed that expression of chemokine monocyte chemoattractant
protein‐1 (MCP‐1/CC chemokine ligand 2 (CCL2)) and its receptor CC chemokine receptor …

Chronic pain, a pathological state, affects millions of people worldwide. Despite decades of
study on the neuronal processing of pain, mechanisms underlying the creation and …

CCL2 chemokine and its receptor CCR2 may contribute to neuropathic pain development.
We tested the hypothesis that injury to peripheral nerves triggers CCL2 release from …

Understanding of the sequence and nature of the events that govern neuron–microglia
communication is critical for the discovery of new mechanisms and targets for chronic pain …

Chemokines and opioids are important regulators of immune, inflammatory and neuronal
responses in peripheral and central pain pathways. Recent studies have provided insights …

The activation of the satellite glial cells (SGCs) surrounding the dorsal root ganglion (DRG)
neurons appears to play a role in pathological pain. We tested the hypothesis that …

Chronic pain represents a major problem in clinical medicine. Whilst the acute pain that is
associated with tissue injury is a protective signal that serves to maintain homeostasis …