Development of polymeric nanoparticles for blood–brain barrier transfer—strategies and challenges

W Zhang, A Mehta, Z Tong, L Esser… - Advanced …, 2021 - Wiley Online Library
Neurological disorders such as Alzheimer's disease, stroke, and brain cancers are difficult to
treat with current drugs as their delivery efficacy to the brain is severely hampered by the …

[HTML][HTML] Polymeric nanoparticles in brain cancer therapy: A review of current approaches

CA Caraway, H Gaitsch, EE Wicks, A Kalluri, N Kunadi… - Polymers, 2022 - mdpi.com
Translation of novel therapies for brain cancer into clinical practice is of the utmost
importance as primary brain tumors are responsible for more than 200,000 deaths …

[HTML][HTML] Dendrimer-based drug delivery systems for brain targeting

Y Zhu, C Liu, Z Pang - Biomolecules, 2019 - mdpi.com
Human neuroscience has made remarkable progress in understanding basic aspects of
functional organization; it is a renowned fact that the blood–brain barrier (BBB) impedes the …

[HTML][HTML] Neuro-nanotechnology: diagnostic and therapeutic nano-based strategies in applied neuroscience

L Shabani, M Abbasi, Z Azarnew, AM Amani… - Biomedical engineering …, 2023 - Springer
Artificial, de-novo manufactured materials (with controlled nano-sized characteristics) have
been progressively used by neuroscientists during the last several decades. The …

Nanoformulation properties, characterization, and behavior in complex biological matrices: Challenges and opportunities for brain-targeted drug delivery applications …

V Agrahari, PA Burnouf, T Burnouf… - Advanced Drug Delivery …, 2019 - Elsevier
Nanocarriers (synthetic/cell-based have attracted enormous interest for various therapeutic
indications, including neurodegenerative disorders. A broader understanding of the impact …

Polymeric dendrimers as nanocarrier vectors for neurotheranostics

H Li, S Zha, H Li, H Liu, KL Wong, AH All - Small, 2022 - Wiley Online Library
Dendrimers are polymers with well‐defined 3D branched structures that are vastly utilized in
various neurotheranostics and biomedical applications, particularly as nanocarrier vectors …

An “amyloid‐β cleaner” for the treatment of Alzheimer's disease by normalizing microglial dysfunction

R Liu, J Yang, L Liu, Z Lu, Z Shi, W Ji, J Shen… - Advanced …, 2020 - Wiley Online Library
Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by
progressive cognitive and memory loss. The vicious circle between dysfunctional microglia …

PAMAM dendrimers: blood-brain barrier transport and neuronal uptake after focal brain ischemia

SD Santos, M Xavier, DM Leite, DA Moreira… - Journal of controlled …, 2018 - Elsevier
Drug delivery to the central nervous system is restricted by the blood-brain barrier (BBB).
However, with the onset of stroke, the BBB becomes leaky, providing a window of …

Therapeutic supramolecular polymers: Designs and applications

H Wang, J Mills, B Sun, H Cui - Progress in Polymer Science, 2023 - Elsevier
The self-assembly of low-molecular-weight building motifs into supramolecular polymers
has unlocked a new realm of materials with distinct properties and tremendous potential for …

Influence factors on and potential strategies to amplify receptor-mediated nanodrug delivery across the blood–brain barrier

Y Wei, X Xia, H Li, H Gao - Expert Opinion on Drug Delivery, 2023 - Taylor & Francis
Introduction A major challenge in treating central nervous system (CNS) disorders is to
achieve adequate drug delivery across the blood–brain barrier (BBB). Receptor-mediated …