Chronic obstructive pulmonary disease (COPD) is a slowly progressing chronic respiratory
disorder. It is characterized by an obstructive ventilatory pattern, which is often partially …

Background The genetic risk factors for susceptibility to chronic obstructive pulmonary
disease (COPD) are still largely unknown. Additional genetic variants are likely to be …

In the US, the burden of asthma and COPD varies across racial or ethnic groups, largely
because of unequal exposure to environmental exposures such as tobacco smoke and …

Rationale: The characterization of young adults who develop late-onset diseases may
augment the detection of novel genes and promote new pathogenic insights. Methods: We …

Background Although chronic obstructive pulmonary disease (COPD) is a common cause of
death and disability, little is known about the effects of socioeconomic status (SES) and race …

Abstract The COPD Genetic Epidemiology (COPDGene®) study provides a rich cross-
sectional dataset of patients with substantial tobacco smoke exposure, varied by race …

Smoking is the leading risk factor for chronic obstructive pulmonary disease (COPD)
worldwide, yet many people who never smoke develop COPD. We perform a longitudinal …

Rationale: The lambda-mu-sigma (LMS) method is a novel approach that defines the lower
limit of normal (LLN) for the ratio of FEV1/FVC as the fifth percentile of the distribution of Z …

Rationale: Racial residential segregation has been associated with worse health outcomes,
but the link with chronic obstructive pulmonary disease (COPD) morbidity has not been …

Recent studies suggest that males with chronic obstructive pulmonary disease (COPD) have
more emphysema than females. It is not known if these differences persist across degrees of …