Kidney fibrosis, characterized by excessive deposition of extracellular matrix (ECM) that
leads to tissue scarring, is the final common outcome of a wide variety of chronic kidney …

Renal fibrosis is a common process of almost all the chronic kidney diseases progressing to
end-stage kidney disease. As a highly conserved lysosomal protein degradation pathway …

Histone lysine crotonylation (Kcr), a novel posttranslational modification, is widespread as
acetylation (Kac); however, its roles are largely unknown. In this study, we report that histone …

Tubular injury and peripheral fibroblast activation are the hallmarks of chronic kidney
disease (CKD), suggesting intimate communication between the two types of cells …

Ageing is a multifactorial biological process leading to a progressive decline of physiological
functions. The process of ageing includes numerous changes in the cells and the …

Chronic kidney disease (CKD) will become the fifth global cause of death by 2040, thus
emphasizing the need to better understand the molecular mechanisms of damage and …

Renal fibrosis (RF) is the common pathological manifestation of virtually all chronic kidney
diseases (CKD) and one of the major causes of end-stage renal disease (ESRD), but the …

Wnt/β-catenin is a developmental signaling pathway that plays a crucial role in driving
kidney fibrosis after injury. Activation of β-catenin is presumed to be regulated through the …

Diabetic kidney disease (DKD) is a chronic complication of diabetes and the leading cause
of end-stage renal disease (ESRD) worldwide. Currently, there are limited therapeutic drugs …

Background: Klotho deficiency is a common feature of premature aging and chronic kidney
disease (CKD). As such, restoring Klotho expression could be a logic strategy for protecting …