New approaches and procedures for cancer treatment: Current perspectives

DT Debela, SGY Muzazu, KD Heraro… - SAGE open …, 2021 - journals.sagepub.com
Cancer is a global health problem responsible for one in six deaths worldwide. Treating
cancer has been a highly complex process. Conventional treatment approaches, such as …

[HTML][HTML] EMT, cancer stem cells and autophagy; The three main axes of metastasis

G Babaei, SGG Aziz, NZZ Jaghi - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Epithelial-mesenchymal transition (EMT) and Cancer stem-like cells (CSCs) are major
factors contributing to the metastasis of cancer cells. Consequently, the signaling pathways …

[HTML][HTML] 5-Fluorouracil (5-FU) resistance and the new strategy to enhance the sensitivity against cancer: Implication of DNA repair inhibition

C Sethy, CN Kundu - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Fluorouracil (5-FU) has been an important anti-cancer drug to date. With an increase in the
knowledge of its mechanism of action, various treatment modalities have been developed …

Cancer metabolism: phenotype, signaling and therapeutic targets

JH Park, WY Pyun, HW Park - Cells, 2020 - mdpi.com
Aberrant metabolism is a major hallmark of cancer. Abnormal cancer metabolism, such as
aerobic glycolysis and increased anabolic pathways, has important roles in tumorigenesis …

[HTML][HTML] Stem cell programs in cancer initiation, progression, and therapy resistance

T Huang, X Song, D Xu, D Tiek, A Goenka, B Wu… - Theranostics, 2020 - ncbi.nlm.nih.gov
Over the past few decades, substantial evidence has convincingly revealed the existence of
cancer stem cells (CSCs) as a minor subpopulation in cancers, contributing to an aberrantly …

Molecular mechanisms of chemo‐and radiotherapy resistance and the potential implications for cancer treatment

YP Liu, CC Zheng, YN Huang, ML He, WW Xu… - MedComm, 2021 - Wiley Online Library
Cancer is a leading cause of death worldwide. Surgery is the primary treatment approach for
cancer, but the survival rate is very low due to the rapid progression of the disease and …

Molecular mechanisms of tumor resistance to radiotherapy

Y Wu, Y Song, R Wang, T Wang - Molecular Cancer, 2023 - Springer
Background Cancer is the most prevalent cause of death globally, and radiotherapy is
considered the standard of care for most solid tumors, including lung, breast, esophageal …

[HTML][HTML] Recent advances in drug delivery systems for targeting cancer stem cells

H Duan, Y Liu, Z Gao, W Huang - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Cancer stem cells (CSCs) are a subpopulation of cancer cells with functions similar to those
of normal stem cells. Although few in number, they are capable of self-renewal, unlimited …

Cancer stem cells and radioresistance: DNA repair and beyond

A Schulz, F Meyer, A Dubrovska, K Borgmann - Cancers, 2019 - mdpi.com
The current preclinical and clinical findings demonstrate that, in addition to the conventional
clinical and pathological indicators that have a prognostic value in radiation oncology, the …

[HTML][HTML] The metabolic mechanisms of breast cancer metastasis

L Wang, S Zhang, X Wang - Frontiers in Oncology, 2021 - frontiersin.org
Breast cancer is one of the most common malignancy among women worldwide. Metastasis
is mainly responsible for treatment failure and is the cause of most breast cancer deaths …