Acute kidney injury is an increasingly common complication of hospital admission and is
associated with high levels of morbidity and mortality. A hypotensive, septic, or toxic insult …

Apoptotic cell death is usually a response to the cell's microenvironment. In the kidney,
apoptosis contributes to parenchymal cell loss in the course of acute and chronic renal …

Understanding the mechanisms of nephron repair is critical for the design of new therapeutic
approaches to treat kidney disease. The kidney can repair after even a severe insult, but …

The mechanism and magnitude by which the mammalian kidney generates and maintains
its proximal tubules, distal tubules, and collecting ducts remain controversial. Here, we use …

Although mesenchymal stromal cells (MSCs) exhibit marked immunoregulatory activity
through multiple mechanisms, their potential to completely evade rejection upon …

Transient reprogramming by the expression of OCT4, SOX2, KLF4 and MYC (OSKM) is a
therapeutic strategy for tissue regeneration and rejuvenation, but little is known about its …

Following kidney injury, repair can result in functional tissue becoming a patch of cells and
disorganized extracellular matrix—a scar—or it can recapitulate the original tissue …

Recently, we have identified a population of renal progenitor cells in human kidneys
showing regenerative potential for injured renal tissue of SCID mice. We demonstrate here …

The prevalence of renal diseases is emerging as a public health problem. Despite major
progress in supportive therapy, mortality rates among patients remain high. In an attempt to …

Background: The adult mammalian heart displays a cardiomyocyte turnover rate of≈ 1%/y
throughout postnatal life and after injuries such as myocardial infarction (MI), but the …