[HTML][HTML] Functionalized liposomes for targeted breast cancer drug delivery

J Nel, K Elkhoury, É Velot, A Bianchi, S Acherar… - Bioactive materials, 2023 - Elsevier
Despite the exceptional progress in breast cancer pathogenesis, prognosis, diagnosis, and
treatment strategies, it remains a prominent cause of female mortality worldwide …

Active targeting of gold nanoparticles as cancer therapeutics

ZR Goddard, MJ Marín, DA Russell… - Chemical Society …, 2020 - pubs.rsc.org
Gold nanoparticles (AuNPs) are of increasing interest for their unique properties and their
biocompatability, minimal toxicity, multivalency and size tunability make them exciting drug …

METTL3 preferentially enhances non-m6A translation of epigenetic factors and promotes tumourigenesis

X Wei, Y Huo, J Pi, Y Gao, S Rao, M He, Q Wei… - Nature cell …, 2022 - nature.com
METTL3 encodes the predominant catalytic enzyme to promote m6A methylation in nucleus.
Recently, accumulating evidence has shown the expression of METTL3 in cytoplasm, but its …

Aptamers as targeted therapeutics: current potential and challenges

J Zhou, J Rossi - Nature reviews Drug discovery, 2017 - nature.com
Nucleic acid aptamers, often termed'chemical antibodies', are functionally comparable to
traditional antibodies, but offer several advantages, including their relatively small physical …

In Vivo Targeting and Positron Emission Tomography Imaging of Tumor with Intrinsically Radioactive Metal–Organic Frameworks Nanomaterials

D Chen, D Yang, CA Dougherty, W Lu, H Wu, X He… - ACS …, 2017 - ACS Publications
Nanoscale metal–organic frameworks (nMOF) materials represent an attractive tool for
various biomedical applications. Due to the chemical versatility, enormous porosity, and …

[HTML][HTML] Impaired ribosome biogenesis: mechanisms and relevance to cancer and aging

Z Turi, M Lacey, M Mistrik, P Moudry - Aging (Albany NY), 2019 - ncbi.nlm.nih.gov
The biosynthesis of ribosomes is a complex process that requires the coordinated action of
many factors and a huge energy investment from the cell. Ribosomes are essential for …

Cancer the 'RBP'eutics–RNA-binding proteins as therapeutic targets for cancer

S Mohibi, X Chen, J Zhang - Pharmacology & therapeutics, 2019 - Elsevier
RNA-binding proteins (RBPs) play a critical role in the regulation of various RNA processes,
including splicing, cleavage and polyadenylation, transport, translation and degradation of …

New perspectives of physiological and pathological functions of nucleolin (NCL)

W Jia, Z Yao, J Zhao, Q Guan, L Gao - Life sciences, 2017 - Elsevier
Nucleolin (NCL) is a multifunctional protein that mainly localized in the nucleolus, it is also
found in the nucleoplasm, cytoplasm and cell membrane. The three main structural domains …

An energy‐storing DNA‐based nanocomplex for laser‐free photodynamic therapy

H Zhao, L Li, F Li, C Liu, M Huang, J Li… - Advanced …, 2022 - Wiley Online Library
Photodynamic therapy (PDT) is a therapeutic strategy that is dependent on external light
irradiation that faces a major challenge in cancer treatment due to the poor tissue …

Aptamer therapeutics in cancer: current and future

Y Morita, M Leslie, H Kameyama, DE Volk, T Tanaka - Cancers, 2018 - mdpi.com
Aptamer-related technologies represent a revolutionary advancement in the capacity to
rapidly develop new classes of targeting ligands. Structurally distinct RNA and DNA …