Obesity and heart failure with preserved ejection fraction (HFpEF) represent two
intermingling epidemics driving perhaps the greatest unmet health problem in …

Sex hormones strongly influence body fat distribution and adipocyte differentiation.
Estrogens and testosterone differentially affect adipocyte physiology, but the importance of …

Objective We compared the effects of high-intensity interval training (HIIT) and moderate-
intensity continuous training (MICT) on insulin sensitivity and other important metabolic …

Metabolomics is a promising approach for the identification of chemical compounds that
serve for early detection, diagnosis, prediction of therapeutic response and prognosis of …

Sedentary people have insulin resistance in their skeletal muscle, but whether this also
occurs in fat cells was unknown. Insulin inhibition of hydrolysis of triglycerides (antilipolysis) …

Objective The aims of this study were: 1) to assess relationships among insulin‐mediated
glucose uptake with standard clinical outcomes and deep‐phenotyping measures (including …

Aims/hypothesis Our aim was to determine the longitudinal associations of individual NEFA
with the pathogenesis of diabetes, specifically with differences in insulin sensitivity and beta …

Upper-body/visceral obesity increases the risk for dyslipidemia, 1 hypertension, 2, 3 and
type 2 diabetes, 4, 5 whereas relatively greater amounts of lower-body fat are independently …

Purpose We studied effects of diet-induced postmenopausal weight loss on gene
expression and activity of proteins involved in lipogenesis and lipolysis in adipose tissue …

Background Obesity-associated inflammation promotes metabolic dysfunction. However, it is
unclear how different inflammatory biomarkers predict dysregulation in specific …