An activator of voltage-gated K+ channels Kv1.1 as a therapeutic candidate for episodic ataxia type 1
I Servettini, G Talani, A Megaro… - Proceedings of the …, 2023 - National Acad Sciences
Loss-of-function mutations in the KCNA1 (Kv1. 1) gene cause episodic ataxia type 1 (EA1), a
neurological disease characterized by cerebellar dysfunction, ataxic attacks, persistent …
neurological disease characterized by cerebellar dysfunction, ataxic attacks, persistent …
De novo variants in KCNA3 cause developmental and epileptic encephalopathy
MV Soldovieri, P Ambrosino, I Mosca… - Annals of …, 2024 - Wiley Online Library
Objective Variants in several potassium channel genes, including KCNA1 and KCNA2,
cause Developmental and Epileptic Encephalopathies (DEEs). We investigated whether …
cause Developmental and Epileptic Encephalopathies (DEEs). We investigated whether …
An orally available Cav2.2 calcium channel inhibitor for the treatment of neuropathic pain
J Kutzsche, GA Guzman, A Willuweit… - British journal of …, 2024 - Wiley Online Library
Abstract Background and Purpose Neuropathic pain affects up to 10% of the global
population and is caused by an injury or a disease affecting the somatosensory, peripheral …
population and is caused by an injury or a disease affecting the somatosensory, peripheral …
[PDF][PDF] An orally available N-type calcium channel inhibitor for the treatment of neuropathic pain
J Kutzsche, GA Guzman, A Willuweit… - British Journal of …, 2023 - researchgate.net
Background and Purpose Neuropathic pain (NP) affects up to 10% of the global population
and is caused by an injury or a disease affecting the somatosensory, peripheral, or central …
and is caused by an injury or a disease affecting the somatosensory, peripheral, or central …
[HTML][HTML] Sympathetic Motor Neuron Dysfunction is a Missing Link in Age-Associated Sympathetic Overactivity
L de la Cruz, D Bui, CM Moreno, O Vivas - bioRxiv, 2023 - ncbi.nlm.nih.gov
Overactivity of the sympathetic nervous system is a hallmark of aging. The cellular
mechanisms behind this overactivity remain poorly understood, with most attention paid to …
mechanisms behind this overactivity remain poorly understood, with most attention paid to …
No Influence of Asundexian on Cardiac Repolarization
C Brase, F Kanefendt, S Loewen… - Clinical …, 2024 - Wiley Online Library
Inhibition of activated factor XI reduces thrombogenesis while maintaining physiological
hemostasis, with the expectation of reduced bleeding risk compared with standard of care in …
hemostasis, with the expectation of reduced bleeding risk compared with standard of care in …