Introduction The purpose of this study was to perform a systematic review and meta-analysis
of exogenous surfactant administration to assess whether this therapy may be useful in adult …

Background Preclinical studies suggest that exogenous surfactant may be of value in the
treatment of the acute respiratory distress syndrome (ARDS), and two phase 2 clinical trials …

Rationale: Patients with acute lung injury have impaired function of the lung surfactant
system. Prior clinical trials have shown that treatment with exogenous recombinant …

Macrophages have a wide variety of activities and it is largely unknown how the diverse
phenotypes of macrophages contribute to pathological conditions in the different types of …

Natural pulmonary surfactant is a complex mixture of lipids and proteins with many
biological functions. Surfactant is responsible for lowering the surface tension within alveoli …

Diving mammals that descend to depths of 50-70 m or greater fully collapse the gas
exchanging portions of their lungs and then reexpand these areas with ascent. To …

Background The COVID-19 pandemic has claimed over 1 million lives globally and results
from the SARS-COV2 virus. COVID-19 is associated with a coagulopathy. In this mixed …

The acute respiratory distress syndrome (ARDS), first described in the medical literature in
1967, 1 consists of the symptom constellation of acute respiratory distress, cyanosis …

As management strategies for acute lung injury (ALI) are shown to have a significant impact
on outcome, it is important to understand the biology, epidemiology, and clinical …

Neonatal respiratory distress syndrome (RDS) is a disease that affects premature infants
born prior to 32 weeks gestation. The main cause is a deficiency in pulmonary surfactant …