Tripterygium wilfordii: An inspiring resource for rheumatoid arthritis treatment

Y Zhang, X Mao, W Li, W Chen, X Wang… - Medicinal research …, 2021 - Wiley Online Library
Abstract Tripterygium wilfordii Hook F (TwHF)based therapy is among the most efficient and
crucial therapeutics for the treatment of rheumatoid arthritis (RA), which indicates that TwHF …

Triptolide: reflections on two decades of research and prospects for the future

L Tong, Q Zhao, E Datan, GQ Lin, I Minn… - Natural product …, 2021 - pubs.rsc.org
Covering: 2000 to 2020 Triptolide is a bioactive diterpene triepoxide isolated from
Tripterygium wilfordii Hook F, a traditional Chinese medicinal plant whose extracts have …

[HTML][HTML] Triptolide: pharmacological spectrum, biosynthesis, chemical synthesis and derivatives

J Gao, Y Zhang, X Liu, X Wu, L Huang, W Gao - Theranostics, 2021 - ncbi.nlm.nih.gov
Triptolide, an abietane-type diterpenoid isolated from Tripterygium wilfordii Hook. F., has
significant pharmacological activity. Research results show that triptolide has obvious …

Celastrol in metabolic diseases: Progress and application prospects

S Xu, Y Feng, W He, W Xu, W Xu, H Yang, X Li - Pharmacological research, 2021 - Elsevier
Metabolic diseases are becoming increasingly common in modern society. Therefore, it is
essential to develop effective drugs or new treatments for metabolic diseases. As an active …

Role of medicinal plants in inhibiting SARS-CoV-2 and in the management of post-COVID-19 complications

PK Mukherjee, T Efferth, B Das, A Kar, S Ghosh… - Phytomedicine, 2022 - Elsevier
Background The worldwide corona virus disease outbreak, generally known as COVID-19
pandemic outbreak resulted in a major health crisis globally. The morbidity and transmission …

Natural plant toxins in honey: An ignored threat to human health

S Yan, K Wang, Y Al Naggar, Y Vander Heyden… - Journal of Hazardous …, 2022 - Elsevier
Consumers often believe that" natural food" is harmless, however naturally occurring toxins
in food represent a health risk to humans. Honey as a natural, nutritious sweetener, is one of …

Tripterygium hypoglaucum (Lévl.) Hutch and Its Main Bioactive Components: Recent Advances in Pharmacological Activity, Pharmacokinetics and Potential Toxicity

J Zhao, F Zhang, X Xiao, Z Wu, Q Hu, Y Jiang… - Frontiers in …, 2021 - frontiersin.org
Tripterygium hypoglaucum (Lévl.) Hutch (THH) is believed to play an important role in health
care and disease treatment according to traditional Chinese medicine. Moreover, it is also …

Toxic effects of Tripterygium glycoside tablets on the reproductive system of male rats by metabolomics, cytotoxicity, and molecular docking

JC Ge, Q Qian, YH Gao, YF Zhang, YX Li, X Wang… - Phytomedicine, 2023 - Elsevier
Background Tripterygium glycoside tablets (TGT) is the most common preparation from
Tripterygium wilfordii Hook F, which is widely used in clinical for treating rheumatoid arthritis …

Triptolide promotes autophagy to inhibit mesangial cell proliferation in IgA nephropathy via the CARD9/p38 MAPK pathway

L Zhao, Z Lan, L Peng, L Wan, D Liu, X Tan… - Cell …, 2022 - Wiley Online Library
Background Mesangial cell proliferation is the most basic pathological feature of
immunoglobulin A nephropathy (IgAN); however, the specific underlying mechanism and an …

Epoxides: Developability as active pharmaceutical ingredients and biochemical probes

B Kaur, P Singh - Bioorganic Chemistry, 2022 - Elsevier
Epoxide functional group is a part of several natural as well as synthetic compounds.
Irrespective of the role of epoxide group in drug efficacy and the use of epoxide compounds …