Managing hypogammaglobulinemia in patients treated with CAR-T-cell therapy: key points for clinicians

E Kampouri, CS Walti, J Gauthier… - Expert Review of …, 2022 - Taylor & Francis
Introduction The unprecedented success of chimeric antigen receptor (CAR)-T-cell therapy
in the management of B-cell malignancies comes with a price of specific side effects …

Infections after chimeric antigen receptor (CAR)‐T‐cell therapy for hematologic malignancies

E Kampouri, JS Little, K Rejeski… - Transplant Infectious …, 2023 - Wiley Online Library
Background Chimeric antigen receptor (CAR)‐T‐cell therapies have revolutionized the
management of acute lymphoblastic leukemia, non‐Hodgkin lymphoma, and multiple …

Challenges for plasma-derived medicinal products

PFW Strengers - Transfusion Medicine and Hemotherapy, 2023 - karger.com
Background: Plasma-derived medicinal products (PDMPs) are medicinal products derived
from human plasma, and a number of PDMPs are listed on the WHO Model List of Essential …

Shortage of plasma-derived products: a looming crisis?

ML Covington, C Voma… - Blood, The Journal of the …, 2022 - ashpublications.org
Plasma, the noncellular component of blood, contains many proteins important for
homeostasis. Deficiencies in plasma components can contribute to the pathogenesis of …

Plasma collection and supply in Europe: proceedings of an International Plasma and Fractionation Association and European Blood Alliance symposium

D Domanović, L von Bonsdorff, P Tiberghien… - Vox …, 2023 - Wiley Online Library
At the symposium organized by the International Plasma and Fractionation Association and
European Blood Alliance, experts presented their views and experiences showing that the …

Hyperimmune globulins for the management of infectious diseases

I Pati, M Cruciani, F Candura, MS Massari, V Piccinini… - Viruses, 2023 - mdpi.com
This review is focused on the use of hyperimmune globulin therapy to treat some infectious
diseases of viral or bacterial origin. Despite the introduction of antibiotics and vaccines …

Anti-inflammatory and immunomodulatory effect of high-dose immunoglobulins in children: from approved indications to off-label use

F Conti, M Moratti, L Leonardi, A Catelli, E Bortolamedi… - Cells, 2023 - mdpi.com
Background: The large-scale utilization of immunoglobulins in patients with inborn errors of
immunity (IEIs) since 1952 prompted the discovery of their key role at high doses as …

Safety of plasmapheresis in donors with low IgG levels: results of a prospective, controlled multicentre study

R Moog, T Laitinen, U Taborski - Transfusion Medicine and …, 2022 - karger.com
Abstract Background and Objectives: Although plasmapheresis is generally considered
safe, there are still concerns about the long-term effects of plasma donation on …

Dealing with immunoglobulin shortages: a rationalization plan from evidence-based and data collection

G Solís-Díez, M Turu-Pedrola… - Frontiers in public …, 2022 - frontiersin.org
Background The demand and consumption of immunoglobulins (IgGs) are growing, and
there are many difficulties in obtaining supplies. The aim of the study was to analyze the …

A global analysis of the use of immunoglobulin, shortages in supply, and mitigating measures: A survey of hospital providers (a BEST Collaborative study)

C So‐Osman, M Delaney, M Fung, W Lu… - …, 2024 - Wiley Online Library
Background Immunoglobulin (IG) therapy is widely used to treat primary and secondary
immune deficiencies and as immunomodulatory agent for various disorders. There is great …