Nanomedicine-mediated regulated cell death in cancer immunotherapy

Y Sun, T Lian, Q Huang, Y Chang, Y Li, X Guo… - Journal of Controlled …, 2023 - Elsevier
Immunotherapy has attracted widespread attention in cancer treatment and has achieved
considerable success in the clinical treatment of some tumors, but it has a low response rate …

Unlocking the potential of pyroptosis in tumor immunotherapy: a new horizon in cancer treatment

Q Yin, SY Song, Y Bian, Y Wang, A Deng, J Lv… - Frontiers in …, 2024 - frontiersin.org
Background The interaction between pyroptosis—a form of programmed cell death—and
tumor immunity represents a burgeoning field of interest. Pyroptosis exhibits a dual role in …

PhotoPyro‐Induced cGAS‐STING Pathway Activation Enhanced Anti‐Melanoma Immunotherapy via a Manganese‐Coordinated Nanomedicine

Y Feng, G Wang, W Li, J Yan, X Yu… - Advanced …, 2024 - Wiley Online Library
Malignant melanoma is an aggressive skin cancer with a high metastatic and mortality rate.
Owing to genetic alterations, melanoma cells are resistant to apoptosis induction, which …

Regulated cell death‐amplified sonodynamic anti‐tumor immune nanotherapeutics

L Zhou, Y Chen, D Xie, K Li, X Cui, CF Dietrich… - …, 2024 - Wiley Online Library
Nanomedicine‐assisted sonodynamic therapy (SDT) has emerged as one of the most
promising cancer therapies due to its unique advantages of high penetration, non‐radiation …

Emerging role of immunogenic cell death in cancer immunotherapy: Advancing next-generation CAR-T cell immunotherapy by combination

Z Zhou, Y Mai, G Zhang, Y Wang, P Sun, Z Jing, Z Li… - Cancer Letters, 2024 - Elsevier
Immunogenic cell death (ICD) is a stress-driven form of regulated cell death (RCD) in which
dying tumor cells' specific signaling pathways are activated to release damage-associated …

Gasdermins: a dual role in pyroptosis and tumor immunity

J Yang, J Jiang - Frontiers in immunology, 2024 - frontiersin.org
The gasdermin (GSDM) protein family plays a pivotal role in pyroptosis, a process critical to
the body's immune response, particularly in combatting bacterial infections, impeding tumor …

Inflammatory cell death induced by 5-aminolevulinic acid-photodynamic therapy initiates anticancer immunity

L Wang, VS Chelakkot, N Newhook, S Tucker… - Frontiers in …, 2023 - frontiersin.org
Background Inflammatory cell death is a form of programmed cell death (PCD) that induces
inflammatory mediators during the process. The production of inflammatory mediators during …

[HTML][HTML] Applications of Pyroptosis Activators in Tumor Immunotherapy

X Bao, M Sun, L Meng, H Zhang, X Yi, P Zhang - Materials Today Bio, 2024 - Elsevier
Contemporary progress in tumor immunotherapy has solidified its role as an effective
approach in combating cancer. Nonetheless, the prevalent “immune cold” state within the …

[HTML][HTML] A new silicon phthalocyanine dye induces pyroptosis in prostate cancer cells during photoimmunotherapy

I Wolf, J Storz, S Schultze-Seemann, PR Esser… - Bioactive Materials, 2024 - Elsevier
Photoimmunotherapy (PIT) combines the specificity of antibodies with the cytotoxicity of light
activatable photosensitizers (PS) and is a promising new cancer therapy. We designed and …

[HTML][HTML] Engineering metal-organic framework nanoparticles trigger pyroptosis to boost colon cancer immunotherapy

X Wang, X Lu, X Yang, B Zhu, W Deng, Q Ye, B Bai… - Materials & Design, 2024 - Elsevier
Pyroptosis, which is a novel form of immunogenic cell death, plays a vital role in antitumor
therapy. Zirconium-based metal–organic frameworks (Zr-MOFs) have been applied in …