The increasing prevalence of antibiotic resistance is a threat to human health, particularly
within vulnerable populations in the hospital and acute care settings. This leads to …

SUMMARY A balanced gut microbiota contributes to health, but the mechanisms
maintaining homeostasis remain elusive. Microbiota assembly during infancy is governed by …

The burden of multidrug resistance in Gram-negative bacilli (GNB) now represents a daily
issue for the management of antimicrobial therapy in intensive care unit (ICU) patients. In …

The massive consumption of antibiotics in the ICU is responsible for substantial ecological
side effects that promote the dissemination of multidrug-resistant bacteria (MDRB) in this …

Objective: To evaluate the potential annual net cost savings of implementing an ICU early
rehabilitation program. Design: Using data from existing publications and actual experience …

The antibiotic pipeline continues to diminish and the majority of the public remains unaware
of this critical situation. The cause of the decline of antibiotic development is multifactorial …

Purpose To concisely describe the current standards of care, major recent advances,
common beliefs that have been contradicted by recent trials, areas of uncertainty, and …

Objective: To evaluate the acquisition rate, identify risk factors, and estimate the risk for
subsequent infection, associated with the colonization of the digestive tract with extended …

Background: The prevalence of extended-spectrum β-lactamase producing
Enterobacteriaceae (ESBL-E) is increasing worldwide. ESBL-E are known to colonize …

Objectives It remains uncertain whether colonization and infection with ESBL-producing
Enterobacteriaceae (ESBL-PE) affect the outcomes for ICU patients. Our objectives were to …