Abstract The Klotho proteins, αKlotho and βKlotho, are essential components of endocrine
fibroblast growth factor (FGF) receptor complexes, as they are required for the high-affinity …

The cushioning function of large arteries encompasses distension during systole and recoil
during diastole which transforms pulsatile flow into a steady flow in the microcirculation …

Objective Use of the frailty index to measure an accumulation of deficits has been proven a
valuable method for identifying elderly people at risk for increased vulnerability, disease …

Patients with chronic kidney disease (CKD) are at an increased risk of premature mortality,
mainly from cardiovascular causes. The association between CKD on hemodialysis and …

Klotho has been recognized as a gene involved in the aging process in mammals for over
30 years, where it regulates phosphate homeostasis and the activity of members of the …

Abstract Introduction The protein Klotho (KL) was first discovered in KL-deficient mice, which
developed a syndrome similar to premature aging in humans. Since then, KL has been …

Cardiovascular disease (CVD) is a major cause of death in patients with chronic kidney
disease (CKD). Both conditions are rising in incidence as well as prevalence, creating poor …

Vitamin D deficiency (< 20 ng/mL) and insufficiency (20–29 ng/mL) are common among
patients with chronic kidney disease (CKD) or undergoing dialysis. In addition to nutritional …

Vascular calcification is a hallmark of atherosclerosis. The location, density, and confluence
of calcification may change portions of the arterial conduit to a noncompliant structure …

Chronic kidney disease (CKD) is associated with the development of mineral bone disorder
(MBD), osteoporosis, and fragility fractures. Among CKD patients, adynamic bone disease or …