Due to the toxicity of widely used corrosion inhibitors and the ever tightening environmental
regulations surrounding their use and disposal, there is great interest in replacing harmful …

Malaria remains a major cause of morbidity and mortality in the tropics, with Plasmodium
falciparum responsible for the majority of the disease burden and P. vivax being the …

Achieving the goal of malaria elimination will depend on targeting Plasmodium pathways
essential across all life stages. Here we identify a lipid kinase, phosphatidylinositol-4-OH …

The quinoline scaffold is prevalent in a variety of pharmacologically active synthetic and
natural compounds. The discovery of chloroquine, the most famous drug containing this …

Malaria elimination has recently been reinstated as a global health priority but current
therapies seem to be insufficient for the task. Elimination efforts require new drug classes …

Artemisinin combination therapies are the first-line treatments for uncomplicated
Plasmodium falciparum malaria in most malaria-endemic countries. Recently, partial …

Primaquine (PQ) is an essential antimalarial drug but despite being developed over 70
years ago, its mode of action is unclear. Here, we demonstrate that hydroxylated-PQ …

The endosomal recycling pathway lies at the heart of the membrane trafficking machinery in
the cell. It plays a central role in determining the composition of the plasma membrane and …

Primaquine Failure and Cytochrome P-450 2D6 in Plasmodium vivax Malaria | New England
Journal of Medicine Skip to main content The New England Journal of Medicine homepage …

Present elimination strategies are based on recommendations derived during the Global
Malaria Eradication Program of the 1960s. However, many countries considering elimination …