The role of B cells in autoimmune diseases involves different cellular functions, including the
well‐established secretion of autoantibodies, autoantigen presentation and ensuing …

B cells have a critical role in the initiation and acceleration of autoimmune diseases,
especially those mediated by autoantibodies. In the peripheral lymphoid system, mature B …

BACKGROUND Type 1 diabetes (T1DM) results from cell-mediated autoimmune destruction
of the β cells of the islets of Langerhans. Autoantibodies directed against the islets are useful …

Type 1 diabetes is an autoimmune disease caused by the immune‐mediated destruction of
insulin‐producing pancreatic β cells. In recent years, the incidence of type 1 diabetes …

Despite growing evidence for a causal role of environmental factors in autoimmune
diseases including the rise in disease frequencies over the past several decades we lack an …

It is widely accepted that Type 1 diabetes is a complex disease. Genetic predisposition and
environmental factors favour the triggering of autoimmune responses against pancreatic β …

Context: Zinc transporter 8 (ZnT8) is a newly discovered islet autoantigen in human type 1A
diabetes (T1D). Objective: The objective was to document changes in ZnT8 autoantibody …

Multiple studies of B-and T-cell compartments and their response to stimuli demonstrate
alterations in established type 1 diabetes (T1D). Yet it is not known whether these alterations …

B cell targeted therapies are becoming widespread for the treatment of multiple autoimmune
diseases including conditions such as Rheumatoid Arthritis, Multiple Sclerosis and Type …

B‐lymphocyte activities are associated with allograft rejection. Interleukin‐10 (IL‐10)‐
expressing B cells, however, exhibit regulatory attributes. Human α1‐antitrypsin (h AAT), a …