Amyotrophic lateral sclerosis (ALS) is a devastating disease caused by degeneration of
motor neurons. As with all major neurodegenerative disorders, development of disease …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder affecting primarily the
motor system, but in which extra‐motor manifestations are increasingly recognized. The loss …

Importance Accurate and up-to-date estimates on incidence, prevalence, mortality, and
disability-adjusted life-years (burden) of neurological disorders are the backbone of …

Neurological disorders are the leading cause of disability and the second leading cause of
death worldwide. In the past 30 years, the absolute numbers of deaths and people with …

Background Neurological disorders are increasingly recognised as major causes of death
and disability worldwide. The aim of this analysis from the Global Burden of Diseases …

Background Amyotrophic lateral sclerosis (ALS) is a global disease, which adversely affects
the life quality of patients and significantly increases the burden of families and society. We …

Introduction: Amyotrophic lateral sclerosis (ALS) is a rare neurological disorder
characterized by progressive deterioration of motor neurons. Assessment of the …

The accumulation of abnormal protein aggregates represents a universal hallmark of
neurodegenerative diseases (NDDs). Post-translational modifications (PTMs) regulate …

Background Experimental observations have suggested a role of infection in the etiology of
neurodegenerative disease. In human studies, however, it is difficult to disentangle whether …

Extracellular vesicles are secreted by a wide variety of cells, and their primary functions
include intercellular communication, immune responses, human reproduction, and synaptic …