Background Friedreich ataxia, an autosomal recessive neurodegenerative and cardiac
disease, is caused by abnormally low levels of frataxin, an essential mitochondrial protein …

Background Cells from individuals with Friedreich's ataxia (FRDA) show reduced activities of
antioxidant enzymes and cannot up-regulate their expression when exposed to oxidative …

The inherited ataxias are a large, heterogeneous group of neurodegenerative disorders
caused by a variety of gene mutations, the effects of which are exerted through different …

Patients with Friedreich ataxia (FRDA) have severely reduced levels of the mitochondrial
protein frataxin, which results from a large GAA triplet-repeat expansion within the frataxin …

DNA and RNA triplexes are thought to play key roles in a range of cellular processes such
as gene regulation and epigenetic remodeling and have been implicated in human disease …

Several studies have shown very positive results regarding the use of serious games as
rehabilitation tools for individuals with physical disabilities, mainly because the game …

As a significant number of individuals has severe motor disabilities, due to neurological
diseases, it is important to provide appropriate rehabilitation programs to improve their …

The number of people with severe physical disabilities is considerable and, therefore, it is
essential to provide a correct physical therapy program to enhance their life quality. Some …

Recent research studies has shown the great contribution that serious games offer in the
area of biomedical rehabilitation of injured persons. Following this trend, we intend to …

Friedreich ataxia (FRDA) is an autosomal recessive degenerative disease primarily affecting
the nervous system and the heart. The identification of the FRDA gene (FXN) encoding the …