Melanin pigment plays a critical role in the protection against the harmful effects of ultraviolet
radiation and other environmental stressors. It is produced by the enzymatic transformation …

Melatonin production is highly conserved in nature through different species including
bacteria, unicellular eukaryotes, algae, plants invertebrates, and vertebrates (Hardeland et …

Cutaneous melanin pigment plays a critical role in camouflage, mimicry, social
communication, and protection against harmful effects of solar radiation. Melanogenesis is …

There is evidence that L‐tyrosine and L‐dihydroxyphenylalanine (L‐DOPA), besides serving
as substrates and intermediates of melanogenesis, are also bioregulatory agents acting not …

Everyone knows and seems to agree that melanocytes are there to generate melanin–an
intriguing, but underestimated multipurpose molecule that is capable of doing far more than …

Dopamine (DA) is a monoamine neurotransmitter of both central and peripheral nervous
system. Its role in the neural–immune communication has been discussed in the present …

Hair is actively pigmented only when it grows: the melanogenic activity of follicular
melanocytes (MC) is strictly coupled to the anagen stage of the hair cycle. In catagen …

The immune and the nervous systems are anatomically closely related and interact with
each other by molecules common to both systems, such as cytokines and neurotransmitters …

Melanoma is a deadly skin cancer that becomes especially difficult to treat after it
metastasizes. Timely identification of melanoma is critical for effective therapy, but …

High mortality rate for metastatic melanoma is related to its resistant to the current methods
of therapy. Melanogenesis is a metabolic pathway characteristic for normal and malignant …