TDM is dead. Long live TCI!

N Holford, G Ma, D Metz - British journal of clinical …, 2022 - Wiley Online Library
Twenty years ago, target concentration intervention (TCI) was distinguished from therapeutic
drug monitoring (TDM). It was proposed that TCI would bring more clinical benefit because …

Point-of-care therapeutic drug monitoring for precision dosing of immunosuppressive drugs

A Taddeo, D Prim, ED Bojescu… - The journal of …, 2020 - academic.oup.com
Background Immunosuppressive drugs (ISD) are an essential tool in the treatment of
transplant rejection and immune-mediated diseases. Therapeutic drug monitoring (TDM) for …

[HTML][HTML] Therapeutic drug monitoring of immunosuppressive drugs in hepatology and gastroenterology

S Udomkarnjananun, MI Francke… - Best Practice & …, 2021 - Elsevier
Immunosuppressive drugs have been key to the success of liver transplantation and are
essential components of the treatment of inflammatory bowel disease (IBD) and autoimmune …

Therapeutic drug monitoring is a feasible tool to personalize drug administration in neonates using new techniques: an overview on the pharmacokinetics and …

DU De Rose, S Cairoli, M Dionisi, A Santisi… - International journal of …, 2020 - mdpi.com
Therapeutic drug monitoring (TDM) should be adopted in all neonatal intensive care units
(NICUs), where the most preterm and fragile babies are hospitalized and treated with many …

Clinical implementation of pharmacogenetics and model‐informed precision dosing to improve patient care

T Mizuno, M Dong, ZL Taylor… - British Journal of …, 2022 - Wiley Online Library
Providing maximal therapeutic efficacy without toxicity is a universal goal of rational drug
therapy. However, substantial between‐patient variability in drug response often impedes …

Precision oncology by point-of-care therapeutic drug monitoring and dosage adjustment of conventional cytotoxic chemotherapies: a perspective

M Briki, P André, Y Thoma, N Widmer, AD Wagner… - Pharmaceutics, 2023 - mdpi.com
Therapeutic drug monitoring (TDM) of conventional cytotoxic chemotherapies is strongly
supported yet poorly implemented in daily practice in hospitals. Analytical methods for the …

Establishment of a fexofenadine population pharmacokinetic (PK)–pharmacodynamic (PD) model and exploration of dosing regimens through simulation

JH Jang, SH Jeong, YB Lee - Journal of Pharmaceutical Investigation, 2023 - Springer
Purpose Fexofenadine is an antihistamine drug used to treat various allergic diseases.
Despite long-term clinical application, research and knowledge on setting dosage regimen …

Bayes‐based dosing of infliximab in inflammatory bowel diseases: short‐term efficacy

E Santacana Juncosa… - British Journal of …, 2021 - Wiley Online Library
Aims Therapeutic drug monitoring of infliximab can guide clinical decisions in patients with
loss of response and in those who can benefit from a de‐intensification. The aim of this study …

Emerging therapeutic drug monitoring technologies: considerations and opportunities in precision medicine

WS Liang, B Beaulieu-Jones, S Smalley… - Frontiers in …, 2024 - frontiersin.org
In recent years, the development of sensor and wearable technologies have led to their
increased adoption in clinical and health monitoring settings. One area that is in early, but …

Should we abandon therapeutic drug monitoring of tacrolimus in whole blood and move to intracellular concentration measurements?

S Udomkarnjananun, T Eiamsitrakoon… - British Journal of …, 2023 - Wiley Online Library
The measurement of whole blood (WB) concentrations has been the primary method for
therapeutic drug monitoring of tacrolimus since its introduction in the field of organ …