TDM is dead. Long live TCI!
Twenty years ago, target concentration intervention (TCI) was distinguished from therapeutic
drug monitoring (TDM). It was proposed that TCI would bring more clinical benefit because …
drug monitoring (TDM). It was proposed that TCI would bring more clinical benefit because …
Point-of-care therapeutic drug monitoring for precision dosing of immunosuppressive drugs
Background Immunosuppressive drugs (ISD) are an essential tool in the treatment of
transplant rejection and immune-mediated diseases. Therapeutic drug monitoring (TDM) for …
transplant rejection and immune-mediated diseases. Therapeutic drug monitoring (TDM) for …
[HTML][HTML] Therapeutic drug monitoring of immunosuppressive drugs in hepatology and gastroenterology
S Udomkarnjananun, MI Francke… - Best Practice & …, 2021 - Elsevier
Immunosuppressive drugs have been key to the success of liver transplantation and are
essential components of the treatment of inflammatory bowel disease (IBD) and autoimmune …
essential components of the treatment of inflammatory bowel disease (IBD) and autoimmune …
Therapeutic drug monitoring is a feasible tool to personalize drug administration in neonates using new techniques: an overview on the pharmacokinetics and …
DU De Rose, S Cairoli, M Dionisi, A Santisi… - International journal of …, 2020 - mdpi.com
Therapeutic drug monitoring (TDM) should be adopted in all neonatal intensive care units
(NICUs), where the most preterm and fragile babies are hospitalized and treated with many …
(NICUs), where the most preterm and fragile babies are hospitalized and treated with many …
Clinical implementation of pharmacogenetics and model‐informed precision dosing to improve patient care
T Mizuno, M Dong, ZL Taylor… - British Journal of …, 2022 - Wiley Online Library
Providing maximal therapeutic efficacy without toxicity is a universal goal of rational drug
therapy. However, substantial between‐patient variability in drug response often impedes …
therapy. However, substantial between‐patient variability in drug response often impedes …
Precision oncology by point-of-care therapeutic drug monitoring and dosage adjustment of conventional cytotoxic chemotherapies: a perspective
Therapeutic drug monitoring (TDM) of conventional cytotoxic chemotherapies is strongly
supported yet poorly implemented in daily practice in hospitals. Analytical methods for the …
supported yet poorly implemented in daily practice in hospitals. Analytical methods for the …
Establishment of a fexofenadine population pharmacokinetic (PK)–pharmacodynamic (PD) model and exploration of dosing regimens through simulation
JH Jang, SH Jeong, YB Lee - Journal of Pharmaceutical Investigation, 2023 - Springer
Purpose Fexofenadine is an antihistamine drug used to treat various allergic diseases.
Despite long-term clinical application, research and knowledge on setting dosage regimen …
Despite long-term clinical application, research and knowledge on setting dosage regimen …
Bayes‐based dosing of infliximab in inflammatory bowel diseases: short‐term efficacy
E Santacana Juncosa… - British Journal of …, 2021 - Wiley Online Library
Aims Therapeutic drug monitoring of infliximab can guide clinical decisions in patients with
loss of response and in those who can benefit from a de‐intensification. The aim of this study …
loss of response and in those who can benefit from a de‐intensification. The aim of this study …
Emerging therapeutic drug monitoring technologies: considerations and opportunities in precision medicine
WS Liang, B Beaulieu-Jones, S Smalley… - Frontiers in …, 2024 - frontiersin.org
In recent years, the development of sensor and wearable technologies have led to their
increased adoption in clinical and health monitoring settings. One area that is in early, but …
increased adoption in clinical and health monitoring settings. One area that is in early, but …
Should we abandon therapeutic drug monitoring of tacrolimus in whole blood and move to intracellular concentration measurements?
S Udomkarnjananun, T Eiamsitrakoon… - British Journal of …, 2023 - Wiley Online Library
The measurement of whole blood (WB) concentrations has been the primary method for
therapeutic drug monitoring of tacrolimus since its introduction in the field of organ …
therapeutic drug monitoring of tacrolimus since its introduction in the field of organ …