Behavioral and neurobiological mechanisms of pavlovian and instrumental extinction learning

ME Bouton, S Maren, GP McNally - Physiological reviews, 2021 - journals.physiology.org
This article reviews the behavioral neuroscience of extinction, the phenomenon in which a
behavior that has been acquired through Pavlovian or instrumental (operant) learning …

Drug-induced conditioned place preference and its practical use in substance use disorder research

G McKendrick, NM Graziane - Frontiers in behavioral neuroscience, 2020 - frontiersin.org
The conditioned place preference (CPP) paradigm is a well-established model utilized to
study the role of context associations in reward-related behaviors, including both natural …

The ins and outs of the striatum: role in drug addiction

LM Yager, AF Garcia, AM Wunsch, SM Ferguson - Neuroscience, 2015 - Elsevier
Addiction is a chronic relapsing disorder characterized by the loss of control over drug
intake, high motivation to obtain the drug, and a persistent craving for the drug …

Animal models of drug relapse and craving after voluntary abstinence: a review

I Fredriksson, M Venniro, DJ Reiner, JJ Chow… - Pharmacological …, 2021 - ASPET
Relapse to drug use during abstinence is a defining feature of addiction. During the last
several decades, this clinical scenario has been studied at the preclinical level using classic …

Animal models of drug relapse and craving: from drug priming-induced reinstatement to incubation of craving after voluntary abstinence

M Venniro, D Caprioli, Y Shaham - Progress in brain research, 2016 - Elsevier
High rates of relapse to drug use during abstinence is a defining feature of drug addiction. In
abstinent drug users, drug relapse is often precipitated by acute exposure to the self …

The reinstatement model of drug relapse: recent neurobiological findings, emerging research topics, and translational research

JM Bossert, NJ Marchant, DJ Calu, Y Shaham - Psychopharmacology, 2013 - Springer
Background and rationale Results from many clinical studies suggest that drug relapse and
craving are often provoked by acute exposure to the self-administered drug or related drugs …

Neural and psychological mechanisms underlying compulsive drug seeking habits and drug memories–indications for novel treatments of addiction

BJ Everitt - European Journal of Neuroscience, 2014 - Wiley Online Library
This review discusses the evidence for the hypothesis that the development of drug
addiction can be understood in terms of interactions between Pavlovian and instrumental …

Intermittent ethanol access schedule in rats as a preclinical model of alcohol abuse

S Carnicella, D Ron, S Barak - Alcohol, 2014 - Elsevier
One of the major challenges in preclinical studies of alcohol abuse and dependence
remains the development of paradigms that will elicit high ethanol intake and mimic the …

On the motivational properties of reward cues: Individual differences

TE Robinson, LM Yager, ES Cogan, BT Saunders - Neuropharmacology, 2014 - Elsevier
Cues associated with rewards, such as food or drugs of abuse, can themselves acquire
motivational properties. Acting as incentive stimuli, such cues can exert powerful control …

Differential roles of medial prefrontal subregions in the regulation of drug seeking

DE Moorman, MH James, EM McGlinchey… - Brain research, 2015 - Elsevier
The prefrontal cortex plays an important role in shaping cognition and behavior. Many
studies have shown that medial prefrontal cortex (mPFC) plays a key role in seeking …