Vascular hyperpermeability, the excessive leakage of fluid and proteins from blood vessels
to the interstitial space, commonly occurs in traumatic and ischemic injuries. This …

Prevention of cardiovascular disease has increasingly important health implications as our
population ages. Menopause is associated with the development of cardiovascular risk …

Abstract β-Catenin, a key regulator of barrier integrity, is an important component of the
adherens junctional complex. Although the roles of β-catenin in maintaining the adherens …

Object: Recent studies have suggested that intrinsic apoptotic signaling cascade is involved
in endothelial barrier dysfunction following hemorrhagic shock (HS), which results in …

Background: Paracellular microvascular hyperpermeability occurs mainly because of the
disruption of the endothelial adherens junction complex. Vascular endothelial-cadherin that …

Recent studies have revealed that an intrinsic apoptotic signaling cascade is involved in
vascular hyperpermeability and endothelial barrier dysfunction. Propofol (2, 6 …

Topical used glucocorticoids (GC) represent an important class of steroid hormones for the
treatment of a broad range of acute or chronical inflammatory diseases. Most interestingly …

BACKGROUND: Mitochondria-mediated apoptotic signaling contributes to microvascular
hyperpermeability. We hypothesized that cyclosporine A (CsA), which protects mitochondrial …

Hemorrhagic shock (HS) result in multiple organ dysfunction syndrome (MODS) and
inflammatory response. It is one of the world's leading causes of death within the first 40 …

Functional integrity of the blood-brain barrier (BBB) is compromised in many neurological
and metabolic pathologies. Cerebral blood vessels are target tissue for sex steroid …