Lipid nanoparticle (LNP) enables mRNA delivery for cancer therapy
Messenger RNA (mRNA) has received great attention in the prevention and treatment of
various diseases due to the success of coronavirus disease 2019 (COVID‐19) mRNA …
various diseases due to the success of coronavirus disease 2019 (COVID‐19) mRNA …
Lipid nanoparticles (LNPs) for in vivo RNA delivery and their breakthrough technology for future applications
RNA therapeutics show a significant breakthrough for the treatment of otherwise incurable
diseases and genetic disorders by regulating disease-related gene expression. The …
diseases and genetic disorders by regulating disease-related gene expression. The …
Strategies for non-viral vectors targeting organs beyond the liver
In recent years, nanoparticles have evolved to a clinical modality to deliver diverse nucleic
acids. Rising interest in nanomedicines comes from proven safety and efficacy profiles …
acids. Rising interest in nanomedicines comes from proven safety and efficacy profiles …
[HTML][HTML] Engineering nanoparticle toolkits for mRNA delivery
The concept of using mRNA to produce its own medicine in situ in the body makes it an ideal
drug candidate, holding great potential to revolutionize the way we approach medicine. The …
drug candidate, holding great potential to revolutionize the way we approach medicine. The …
Solid lipid nanoparticles vs. nanostructured lipid carriers: a comparative review
Solid–lipid nanoparticles and nanostructured lipid carriers are delivery systems for the
delivery of drugs and other bioactives used in diagnosis, therapy, and treatment procedures …
delivery of drugs and other bioactives used in diagnosis, therapy, and treatment procedures …
The interplay of quaternary ammonium lipid structure and protein corona on lung-specific mRNA delivery by selective organ targeting (SORT) nanoparticles
Messenger RNA (mRNA) can treat genetic disease using protein replacement or genome
editing approaches but requires a suitable carrier to circumnavigate biological barriers and …
editing approaches but requires a suitable carrier to circumnavigate biological barriers and …
Messenger RNA-based therapeutics and vaccines: what's beyond COVID-19?
With the rapid success in the development of mRNA vaccines against COVID-19 and with a
number of mRNA-based drugs ahead in the pipelines, mRNA has catapulted to the forefront …
number of mRNA-based drugs ahead in the pipelines, mRNA has catapulted to the forefront …
Engineering extracellular vesicles as delivery systems in therapeutic applications
L Wang, D Wang, Z Ye, J Xu - Advanced Science, 2023 - Wiley Online Library
Extracellular vesicles (EVs) are transport vesicles secreted by living cells and released into
the extracellular environment. Recent studies have shown that EVs serve as “messengers” …
the extracellular environment. Recent studies have shown that EVs serve as “messengers” …
Chemically modified platforms for better RNA therapeutics
RNA-based therapies have catalyzed a revolutionary transformation in the biomedical
landscape, offering unprecedented potential in disease prevention and treatment. However …
landscape, offering unprecedented potential in disease prevention and treatment. However …
Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy
Q Lu, D Kou, S Lou, M Ashrafizadeh, AR Aref… - Journal of Hematology & …, 2024 - Springer
Cancer immunotherapy and vaccine development have significantly improved the fight
against cancers. Despite these advancements, challenges remain, particularly in the clinical …
against cancers. Despite these advancements, challenges remain, particularly in the clinical …