Owing to the dysregulation of protein kinase activity in many diseases including cancer, this
enzyme family has become one of the most important drug targets in the 21 st century. There …

Owing to the dysregulation of protein kinase activity in many diseases including cancer, this
enzyme family has become one of the most important drug targets in the 21 st century. There …

The Janus kinase (JAK) family of nonreceptor protein-tyrosine kinases consists of JAK1,
JAK2, JAK3, and TYK2 (Tyrosine Kinase 2). Each of these proteins contains a JAK …

Psoriasis is a heterogeneous, inflammatory, autoimmune skin disease that affects up to 2%
of the world's population. There are many treatment modalities including topical medicines …

The altered activation or overexpression of protein kinases (PKs) is a major subject of
research in oncology and their inhibition using small molecules, protein kinases inhibitors …

Owing to genetic alterations and overexpression, the dysregulation of protein kinases plays
a significant role in the pathogenesis of many autoimmune and neoplastic disorders and …

Following nearly two decades of development, significant advancements have been
achieved in PROTAC technology. As of the end of 2022, more than 20 drugs have entered …

Acidic extracellular pH is a major characteristic of tumor tissue, studies suggest that the local
pH value of malignant tumor tissues is between 6.0 and 6.9. Acid-sensing ion channel 1 …

Because genetic alterations including mutations, overexpression, translocations, and
dysregulation of protein kinases are involved in the pathogenesis of many illnesses, this …

Kidney cancers comprise about 3% of all new malignancies in the United States. Renal cell
carcinomas (RCCs) are the most common type of renal malignancy making up about 85% of …