[PDF][PDF] Five years of GWAS discovery
The past five years have seen many scientific and biological discoveries made through the
experimental design of genome-wide association studies (GWASs). These studies were …
experimental design of genome-wide association studies (GWASs). These studies were …
Genome-wide association studies in diverse populations
NA Rosenberg, L Huang, EM Jewett… - Nature Reviews …, 2010 - nature.com
Genome-wide association (GWA) studies have identified a large number of SNPs
associated with disease phenotypes. As most GWA studies have been performed in …
associated with disease phenotypes. As most GWA studies have been performed in …
Sensitive detection of chromosomal segments of distinct ancestry in admixed populations
AL Price, A Tandon, N Patterson, KC Barnes… - PLoS …, 2009 - journals.plos.org
Identifying the ancestry of chromosomal segments of distinct ancestry has a wide range of
applications from disease mapping to learning about history. Most methods require the use …
applications from disease mapping to learning about history. Most methods require the use …
Ancestry informative marker sets for determining continental origin and admixture proportions in common populations in America
To provide a resource for assessing continental ancestry in a wide variety of genetic studies,
we identified, validated, and characterized a set of 128 ancestry informative markers (AIMs) …
we identified, validated, and characterized a set of 128 ancestry informative markers (AIMs) …
A genome-wide perspective on the evolutionary history of enigmatic wolf-like canids
JP Pollinger, DA Earl, JC Knowles, AR Boyko… - Genome …, 2011 - genome.cshlp.org
High-throughput genotyping technologies developed for model species can potentially
increase the resolution of demographic history and ancestry in wild relatives. We use a SNP …
increase the resolution of demographic history and ancestry in wild relatives. We use a SNP …
Geographic patterns of genome admixture in Latin American Mestizos
The large and diverse population of Latin America is potentially a powerful resource for
elucidating the genetic basis of complex traits through admixture mapping. However, no …
elucidating the genetic basis of complex traits through admixture mapping. However, no …
Development of a panel of genome-wide ancestry informative markers to study admixture throughout the Americas
JM Galanter, JC Fernandez-Lopez, CR Gignoux… - PLoS …, 2012 - journals.plos.org
Most individuals throughout the Americas are admixed descendants of Native American,
European, and African ancestors. Complex historical factors have resulted in varying …
European, and African ancestors. Complex historical factors have resulted in varying …
[PDF][PDF] Estimating local ancestry in admixed populations
S Sankararaman, S Sridhar, G Kimmel… - The American Journal of …, 2008 - cell.com
Large-scale genotyping of SNPs has shown a great promise in identifying markers that
could be linked to diseases. One of the major obstacles involved in performing these studies …
could be linked to diseases. One of the major obstacles involved in performing these studies …
PCA-correlated SNPs for structure identification in worldwide human populations
Existing methods to ascertain small sets of markers for the identification of human population
structure require prior knowledge of individual ancestry. Based on Principal Components …
structure require prior knowledge of individual ancestry. Based on Principal Components …
A panel of ancestry informative markers for estimating individual biogeographical ancestry and admixture from four continents: utility and applications
Autosomal ancestry informative markers (AIMs) are useful for inferring individual
biogeographical ancestry (I‐BGA) and admixture. Ancestry estimates obtained from Y and …
biogeographical ancestry (I‐BGA) and admixture. Ancestry estimates obtained from Y and …