[PDF][PDF] Five years of GWAS discovery

PM Visscher, MA Brown, MI McCarthy… - The American Journal of …, 2012 - cell.com
The past five years have seen many scientific and biological discoveries made through the
experimental design of genome-wide association studies (GWASs). These studies were …

Genome-wide association studies in diverse populations

NA Rosenberg, L Huang, EM Jewett… - Nature Reviews …, 2010 - nature.com
Genome-wide association (GWA) studies have identified a large number of SNPs
associated with disease phenotypes. As most GWA studies have been performed in …

Sensitive detection of chromosomal segments of distinct ancestry in admixed populations

AL Price, A Tandon, N Patterson, KC Barnes… - PLoS …, 2009 - journals.plos.org
Identifying the ancestry of chromosomal segments of distinct ancestry has a wide range of
applications from disease mapping to learning about history. Most methods require the use …

Ancestry informative marker sets for determining continental origin and admixture proportions in common populations in America

R Kosoy, R Nassir, C Tian, PA White, LM Butler… - Human …, 2009 - Wiley Online Library
To provide a resource for assessing continental ancestry in a wide variety of genetic studies,
we identified, validated, and characterized a set of 128 ancestry informative markers (AIMs) …

A genome-wide perspective on the evolutionary history of enigmatic wolf-like canids

JP Pollinger, DA Earl, JC Knowles, AR Boyko… - Genome …, 2011 - genome.cshlp.org
High-throughput genotyping technologies developed for model species can potentially
increase the resolution of demographic history and ancestry in wild relatives. We use a SNP …

Geographic patterns of genome admixture in Latin American Mestizos

S Wang, N Ray, W Rojas, MV Parra, G Bedoya… - PLoS …, 2008 - journals.plos.org
The large and diverse population of Latin America is potentially a powerful resource for
elucidating the genetic basis of complex traits through admixture mapping. However, no …

Development of a panel of genome-wide ancestry informative markers to study admixture throughout the Americas

JM Galanter, JC Fernandez-Lopez, CR Gignoux… - PLoS …, 2012 - journals.plos.org
Most individuals throughout the Americas are admixed descendants of Native American,
European, and African ancestors. Complex historical factors have resulted in varying …

[PDF][PDF] Estimating local ancestry in admixed populations

S Sankararaman, S Sridhar, G Kimmel… - The American Journal of …, 2008 - cell.com
Large-scale genotyping of SNPs has shown a great promise in identifying markers that
could be linked to diseases. One of the major obstacles involved in performing these studies …

PCA-correlated SNPs for structure identification in worldwide human populations

P Paschou, E Ziv, EG Burchard, S Choudhry… - PLoS …, 2007 - journals.plos.org
Existing methods to ascertain small sets of markers for the identification of human population
structure require prior knowledge of individual ancestry. Based on Principal Components …

A panel of ancestry informative markers for estimating individual biogeographical ancestry and admixture from four continents: utility and applications

I Halder, M Shriver, M Thomas, JR Fernandez… - Human …, 2008 - Wiley Online Library
Autosomal ancestry informative markers (AIMs) are useful for inferring individual
biogeographical ancestry (I‐BGA) and admixture. Ancestry estimates obtained from Y and …