Cell-associated HIV RNA: a dynamic biomarker of viral persistence

AO Pasternak, VV Lukashov, B Berkhout - Retrovirology, 2013 - Springer
In most HIV-infected individuals adherent to modern antiretroviral therapy (ART), plasma
viremia stays undetectable by clinical assays and therefore, additional virological markers …

The alphabet soup of HIV reservoir markers

RR Sharaf, JZ Li - Current HIV/AIDS Reports, 2017 - Springer
Abstract Purpose of Review Despite the success of antiretroviral therapy in suppressing HIV,
life-long therapy is required to avoid HIV reactivation from long-lived viral reservoirs …

The largest HIV-1-infected T cell clones in children on long-term combination antiretroviral therapy contain solo LTRs

JC Botha, D Demirov, C Gordijn, MG Katusiime… - Mbio, 2023 - Am Soc Microbiol
Combination antiretroviral therapy (cART) suppresses viral replication but does not cure HIV
infection because a reservoir of infectious (intact) HIV proviruses persists in long-lived CD4+ …

Kinetics of TTV Loads in Peripheral Blood Mononuclear Cells of Early Treated Acute HIV Infections

I Abbate, G Rozera, E Cimini, F Carletti, E Tartaglia… - Viruses, 2023 - mdpi.com
Torquetenovirus (TTV) is the most abundant component of the human blood virome and its
replication is controlled by a functioning immune system. In this study, TTV replication was …

Quantification of total HIV DNA as a marker to measure viral reservoir: methods and potential implications for clinical practice

S Belmonti, S Di Giambenedetto, F Lombardi - Diagnostics, 2021 - mdpi.com
The focus of this review is to examine the importance of quantifying total HIV DNA to target
the HIV reservoir and the clinical implications and challenges involved in its future …

Myeloid derived suppressor cells expansion persists after early ART and may affect CD4 T cell recovery

C Agrati, N Tumino, V Bordoni, C Pinnetti… - Frontiers in …, 2019 - frontiersin.org
Myeloid-derived suppressor cells (MDSC) are expanded during HIV-1 infection and
correlated with disease progression. MDSC expand in the early phase of primary infection …

Quantification of viral DNA during HIV-1 infection: A review of relevant clinical uses and laboratory methods

EK Alidjinou, L Bocket, D Hober - Pathologie Biologie, 2015 - Elsevier
Effective antiretroviral therapy usually leads to undetectable HIV-1 RNA in the plasma.
However, the virus persists in some cells of infected patients as various DNA forms, both …

HIV antigen-specific reactivation of HIV infection from cellular reservoirs: implications in the settings of therapeutic vaccinations

A Shete, M Thakar, DP Singh… - AIDS research and …, 2012 - liebertpub.com
Therapeutic vaccinations using human immunodeficiency virus (HIV) antigens in HIV-
infected patients on antiretroviral therapy (ART) have so far been attempted with the purpose …

[HTML][HTML] Analysis of co‐receptor usage of circulating viral and proviral HIV genome quasispecies by ultra‐deep pyrosequencing in patients who are candidates for …

I Abbate, G Rozera, C Tommasi, A Bruselles… - Clinical microbiology …, 2011 - Elsevier
UDPS combined with genotypic algorithms for prediction of HIV‐1 co‐receptor usage may
provide quantitative data about the tropism of each variant present in the viral quasispecies …

The dual-target approach in viral HIV-1 viremia testing: An added value to virological monitoring?

A Amendola, G Sberna, F Forbici, I Abbate, P Lorenzini… - PloS one, 2020 - journals.plos.org
New methods of HIV-1 RNA quantification based on dual-target detection are increasingly
used in HIV viral load monitoring, but clinical implications and impact of dual-target detection …