Epidermal growth factor receptor targeting in cancer: a review of trends and strategies
The epidermal growth factor receptor (EGFR) is a cell-surface receptor belonging to ErbB
family of tyrosine kinase and it plays a vital role in the regulation of cell proliferation, survival …
family of tyrosine kinase and it plays a vital role in the regulation of cell proliferation, survival …
Molecular mechanisms of drug resistance
DB Longley, PG Johnston - The Journal of Pathology: A Journal …, 2005 - Wiley Online Library
Resistance to chemotherapy limits the effectiveness of anti‐cancer drug treatment. Tumours
may be intrinsically drug‐resistant or develop resistance to chemotherapy during treatment …
may be intrinsically drug‐resistant or develop resistance to chemotherapy during treatment …
Bax/Bcl-2 cascade is regulated by the EGFR pathway: therapeutic targeting of non-small cell lung cancer
Non-small cell lung carcinoma (NSCLC) comprises 80%–85% of lung cancer cases. EGFR
is involved in several cancer developments, including NSCLC. The EGFR pathway …
is involved in several cancer developments, including NSCLC. The EGFR pathway …
Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non–small-cell lung cancer
F Cappuzzo, FR Hirsch, E Rossi… - Journal of the …, 2005 - academic.oup.com
Background: Gefitinib is a selective inhibitor of the epidermal growth factor (EGFR) tyrosine
kinase, which is overexpressed in many cancers, including non–small-cell lung cancer …
kinase, which is overexpressed in many cancers, including non–small-cell lung cancer …
Epidermal growth factor receptor biology in head and neck cancer
S Kalyankrishna, JR Grandis - Journal of clinical oncology, 2006 - ascopubs.org
Epidermal growth factor receptor (EGFR) is overexpressed in several epithelial
malignancies, including head and neck squamous cell carcinoma (HNSCC), which exhibits …
malignancies, including head and neck squamous cell carcinoma (HNSCC), which exhibits …
Progress and promise of FDG-PET imaging for cancer patient management and oncologic drug development
GJ Kelloff, JM Hoffman, B Johnson, HI Scher… - Clinical Cancer …, 2005 - AACR
[18F] Fluoro-2-deoxyglucose positron emission tomography (FDG-PET) assesses a
fundamental property of neoplasia, the Warburg effect. This molecular imaging technique …
fundamental property of neoplasia, the Warburg effect. This molecular imaging technique …
Analysis of Epidermal Growth Factor Receptor Gene Mutation in Patients with Non–Small Cell Lung Cancer and Acquired Resistance to Gefitinib
T Kosaka, Y Yatabe, H Endoh, K Yoshida, T Hida… - Clinical Cancer …, 2006 - AACR
Purpose: Non–small cell lung cancers carrying activating mutations in the gene for the
epidermal growth factor receptor (EGFR) are highly sensitive to EGFR-specific tyrosine …
epidermal growth factor receptor (EGFR) are highly sensitive to EGFR-specific tyrosine …
The function of LncRNAs and their role in the prediction, diagnosis, and prognosis of lung cancer
Lung cancer remains a major threat to human health. Low dose CT scan (LDCT) has
become the main method of early screening for lung cancer due to the low sensitivity of …
become the main method of early screening for lung cancer due to the low sensitivity of …
PI3K/Akt/mTOR pathway as a target for cancer therapy
D Morgensztern, HL McLeod - Anti-cancer drugs, 2005 - journals.lww.com
Abstract The PI3K/Akt/mTOR pathway regulates several normal cellular functions that are
also critical for tumorigenesis, including cellular proliferation, growth, survival and mobility …
also critical for tumorigenesis, including cellular proliferation, growth, survival and mobility …
Predictive and prognostic impact of epidermal growth factor receptor mutation in non–small-cell lung cancer patients treated with gefitinib
Purpose This study was undertaken to investigate the effects of epidermal growth factor
receptor (EGFR) mutation and its downstream signaling on response and survival in non …
receptor (EGFR) mutation and its downstream signaling on response and survival in non …