HIF-1α regulates bone homeostasis and angiogenesis, participating in the occurrence of bone metabolic diseases

W Chen, P Wu, F Yu, G Luo, L Qing, J Tang - Cells, 2022 - mdpi.com
In the physiological condition, the skeletal system's bone resorption and formation are in
dynamic balance, called bone homeostasis. However, bone homeostasis is destroyed under …

Insight in Hypoxia‐Mimetic Agents as Potential Tools for Mesenchymal Stem Cell Priming in Regenerative Medicine

A Nowak-Stępniowska, PN Osuchowska… - Stem Cells …, 2022 - Wiley Online Library
Hypoxia‐mimetic agents are new potential tools in MSC priming instead of hypoxia
incubators or chambers. Several pharmaceutical/chemical hypoxia‐mimetic agents can be …

Dynamic changes of the bone marrow niche: mesenchymal stromal cells and their progeny during aging and leukemia

K Woods, B Guezguez - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Mesenchymal stromal cells (MSCs) are a heterogenous cell population found in a wide
range of tissues in the body, known for their nutrient-producing and immunomodulatory …

Extracellular vesicles and their roles in the tumor immune microenvironment

A Reale, T Khong, A Spencer - Journal of Clinical Medicine, 2022 - mdpi.com
Tumor cells actively incorporate molecules (eg, proteins, lipids, RNA) into particles named
extracellular vesicles (EVs). Several groups have demonstrated that EVs can be transferred …

Drug Resistance: The role of Exosomal miRNA in the microenvironment of hematopoietic tumors

M Cariello, A Squilla, M Piacente, G Venutolo… - Molecules, 2022 - mdpi.com
Extracellular vesicles (EVs), including exosomes, have an important role thanks to their
ability to communicate and exchange information between tumor cells and the tumor …

Enhancing the anti-leukemia immunity of acute lymphocytic leukemia-derived exosome-based vaccine by downregulation of PD-L1 expression

F Huang, Z Li, W Zhang, J Li, S Hao - Cancer Immunology …, 2022 - Springer
Cell-released nanovesicles can induce anti-leukemia immunity. Leukemia cell-derived
exosomes (LEXs) are promising anti-tumor vaccine components for cancer immunotherapy …

The role of exosomes in the stemness maintenance and progression of acute myeloid leukemia

Q Li, M Wang, L Liu - Biochemical Pharmacology, 2023 - Elsevier
Acute myeloid leukemia (AML) is an aggressive malignancy of myeloid hematopoietic cells,
which is characterized by the aberrant clonal proliferation of immature myeloblasts and …

Tumorigenic and tumoricidal properties of exosomes in cancers; a forward look

Z Abbasi-Malati, SG Azizi, SZ Milani, ZA Serej… - Cell Communication and …, 2024 - Springer
In recent decades, emerging data have highlighted the critical role of extracellular vesicles
(EVs), especially (exosomes) Exos, in the progression and development of several cancer …

Bone marrow vasculature advanced in vitro models for cancer and cardiovascular research

M Campanile, L Bettinelli, C Cerutti… - Frontiers in …, 2023 - frontiersin.org
Cardiometabolic diseases and cancer are among the most common diseases worldwide
and are a serious concern to the healthcare system. These conditions, apparently distant …

Properties of leukemic stem cells in regulating drug resistance in acute and chronic myeloid leukemias

X Zhai, X Jiang - Biomedicines, 2022 - mdpi.com
Notoriously known for their capacity to reconstitute hematological malignancies in vivo,
leukemic stem cells (LSCs) represent key drivers of therapeutic resistance and disease …