HIF-1α regulates bone homeostasis and angiogenesis, participating in the occurrence of bone metabolic diseases
W Chen, P Wu, F Yu, G Luo, L Qing, J Tang - Cells, 2022 - mdpi.com
In the physiological condition, the skeletal system's bone resorption and formation are in
dynamic balance, called bone homeostasis. However, bone homeostasis is destroyed under …
dynamic balance, called bone homeostasis. However, bone homeostasis is destroyed under …
Insight in Hypoxia‐Mimetic Agents as Potential Tools for Mesenchymal Stem Cell Priming in Regenerative Medicine
A Nowak-Stępniowska, PN Osuchowska… - Stem Cells …, 2022 - Wiley Online Library
Hypoxia‐mimetic agents are new potential tools in MSC priming instead of hypoxia
incubators or chambers. Several pharmaceutical/chemical hypoxia‐mimetic agents can be …
incubators or chambers. Several pharmaceutical/chemical hypoxia‐mimetic agents can be …
Dynamic changes of the bone marrow niche: mesenchymal stromal cells and their progeny during aging and leukemia
K Woods, B Guezguez - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Mesenchymal stromal cells (MSCs) are a heterogenous cell population found in a wide
range of tissues in the body, known for their nutrient-producing and immunomodulatory …
range of tissues in the body, known for their nutrient-producing and immunomodulatory …
Extracellular vesicles and their roles in the tumor immune microenvironment
Tumor cells actively incorporate molecules (eg, proteins, lipids, RNA) into particles named
extracellular vesicles (EVs). Several groups have demonstrated that EVs can be transferred …
extracellular vesicles (EVs). Several groups have demonstrated that EVs can be transferred …
Drug Resistance: The role of Exosomal miRNA in the microenvironment of hematopoietic tumors
M Cariello, A Squilla, M Piacente, G Venutolo… - Molecules, 2022 - mdpi.com
Extracellular vesicles (EVs), including exosomes, have an important role thanks to their
ability to communicate and exchange information between tumor cells and the tumor …
ability to communicate and exchange information between tumor cells and the tumor …
Enhancing the anti-leukemia immunity of acute lymphocytic leukemia-derived exosome-based vaccine by downregulation of PD-L1 expression
F Huang, Z Li, W Zhang, J Li, S Hao - Cancer Immunology …, 2022 - Springer
Cell-released nanovesicles can induce anti-leukemia immunity. Leukemia cell-derived
exosomes (LEXs) are promising anti-tumor vaccine components for cancer immunotherapy …
exosomes (LEXs) are promising anti-tumor vaccine components for cancer immunotherapy …
The role of exosomes in the stemness maintenance and progression of acute myeloid leukemia
Q Li, M Wang, L Liu - Biochemical Pharmacology, 2023 - Elsevier
Acute myeloid leukemia (AML) is an aggressive malignancy of myeloid hematopoietic cells,
which is characterized by the aberrant clonal proliferation of immature myeloblasts and …
which is characterized by the aberrant clonal proliferation of immature myeloblasts and …
Tumorigenic and tumoricidal properties of exosomes in cancers; a forward look
Z Abbasi-Malati, SG Azizi, SZ Milani, ZA Serej… - Cell Communication and …, 2024 - Springer
In recent decades, emerging data have highlighted the critical role of extracellular vesicles
(EVs), especially (exosomes) Exos, in the progression and development of several cancer …
(EVs), especially (exosomes) Exos, in the progression and development of several cancer …
Bone marrow vasculature advanced in vitro models for cancer and cardiovascular research
M Campanile, L Bettinelli, C Cerutti… - Frontiers in …, 2023 - frontiersin.org
Cardiometabolic diseases and cancer are among the most common diseases worldwide
and are a serious concern to the healthcare system. These conditions, apparently distant …
and are a serious concern to the healthcare system. These conditions, apparently distant …
Properties of leukemic stem cells in regulating drug resistance in acute and chronic myeloid leukemias
X Zhai, X Jiang - Biomedicines, 2022 - mdpi.com
Notoriously known for their capacity to reconstitute hematological malignancies in vivo,
leukemic stem cells (LSCs) represent key drivers of therapeutic resistance and disease …
leukemic stem cells (LSCs) represent key drivers of therapeutic resistance and disease …