Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host
response to an infection. This recently implemented definition does not capture the …

Sepsis and septic shock remain drivers for morbidity and mortality in critical illness. The
clinical picture of patients presenting with these syndromes evolves rapidly and may be …

Sepsis is characterized by a dysregulated immune response to infections that causes life-
threatening organ dysfunction and even death. When infections occur, bacterial cell wall …

Pyroptosis is inflammation-associated caspase-1-dependent programmed cell death, which
confers a crucial role in sepsis. The present study intends to investigate the regulatory …

Sepsis and trauma were the primary inciting events. With tremendous the advances in care
over the ensuing four decades, the epidemiology of MOF evolved from a fulminant …

Sepsis is an ill-defined syndrome yet is a leading cause of morbidity and mortality
worldwide. The most recent consensus defines sepsis as life-threatening organ dysfunction …

Background The main cause of high mortality from sepsis is that immunosuppression leads
to life-threatening organ dysfunction, and reversing immunosuppression is key to sepsis …

Background Sepsis is a complex health condition, leading to long-term morbidity and
mortality. Understanding the risk factors for recurrent sepsis, as well as its impact on mid-and …

Sepsis, a critical condition marked by systemic inflammation, profoundly impacts both innate
and adaptive immunity, often resulting in lymphopenia. This immune alteration can spare …

Summary Persistent Inflammation, Immunosuppression, and Catabolism Syndrome (PICS)
is a clinical endotype of chronic critical illness. PICS consists of a self-perpetuating cycle of …