Point of care diagnostics: status and future

V Gubala, LF Harris, AJ Ricco, MX Tan… - Analytical …, 2012 - ACS Publications
We review point-of-care (POC) diagnostics, in vitro diagnostic (IVD) tests that do not involve
the use of laboratory staff and facilities to provide the result. The analytical “targets” include …

[HTML][HTML] Systematic reviews and meta-analyses of diagnostic test accuracy

MMG Leeflang - Clinical Microbiology and Infection, 2014 - Elsevier
Systematic reviews of diagnostic test accuracy summarize the accuracy, eg the sensitivity
and specificity, of diagnostic tests in a systematic and transparent way. The aim of such a …

Point‐of‐care diagnosis of tuberculosis: Past, present and future

K Dheda, M Ruhwald, G Theron, J Peter… - Respirology, 2013 - Wiley Online Library
Diagnosis represents only one aspect of tuberculosis (TB) control but is perhaps one of the
most challenging. The drawbacks of current tools highlight several unmet needs in TB …

Diagnostic accuracy of a urine lipoarabinomannan strip-test for TB detection in HIV-infected hospitalised patients

JG Peter, G Theron, R van Zyl-Smit… - European respiratory …, 2012 - Eur Respiratory Soc
Lack of point-of-care tests for tuberculosis (TB) result in diagnostic delay, and increased
mortality and healthcare-related costs. The urine DetermineTM TB-LAM point-of-care strip …

Diagnosis and treatment of paediatric tuberculosis: an insight review

N Mandal, PK Anand, S Gautam, S Das… - Critical reviews in …, 2017 - Taylor & Francis
Tuberculosis (TB) is a major public health problem, invading all age groups world-wide. It is
an opportunistic infection affecting the individuals alone or with co-infections. Childhood TB …

[HTML][HTML] Sensitive electrochemiluminescence (ECL) immunoassays for detecting lipoarabinomannan (LAM) and ESAT-6 in urine and serum from tuberculosis patients

T Broger, M Tsionksy, A Mathew, TL Lowary, A Pinter… - PLoS …, 2019 - journals.plos.org
Background Tuberculosis (TB) infection was responsible for an estimated 1.3 million deaths
in 2017. Better diagnostic tools are urgently needed. We sought to determine whether …

Biomarkers for tuberculosis: the case for lipoarabinomannan

M Correia-Neves, G Fröberg, L Korshun… - ERJ open …, 2019 - Eur Respiratory Soc
Tuberculosis (TB) is considered the most onerous of infectious diseases according to recent
reports from the World Health Organization. Available tests for TB diagnosis present severe …

[HTML][HTML] The diagnostic accuracy of urine-based Xpert MTB/RIF in HIV-infected hospitalized patients who are smear-negative or sputum scarce

JG Peter, G Theron, TE Muchinga, U Govender… - PloS one, 2012 - journals.plos.org
Background Hospitals in sub-Saharan Africa are inundated with HIV-infected patients and
tuberculosis (TB) is the commonest opportunistic infection in this sub-group. Up to one third …

Recent tuberculosis diagnosis toward the end TB strategy

SA Cheon, HH Cho, J Kim, J Lee, HJ Kim… - Journal of microbiological …, 2016 - Elsevier
Tuberculosis (TB) is an infectious bacterial disease caused by Mycobacterium tuberculosis.
Despite global TB eradication efforts, it is still a global public health concern, especially in …

[HTML][HTML] Using phage and yeast display to select hundreds of monoclonal antibodies: application to antigen 85, a tuberculosis biomarker

F Ferrara, LA Naranjo, S Kumar, T Gaiotto… - PloS one, 2012 - journals.plos.org
Background Current diagnostic methods for tuberculosis (TB), a major global health
challenge that kills nearly two million people annually, are time-consuming and inadequate …