Importance Mendelian randomization (MR) studies use genetic variation associated with
modifiable exposures to assess their possible causal relationship with outcomes and aim to …

Evidence on the validity of drug targets from randomized trials is reliable but typically
expensive and slow to obtain. In contrast, evidence from conventional observational …

Mendelian randomisation (MR) studies allow a better understanding of the causal effects of
modifiable exposures on health outcomes, but the published evidence is often hampered by …

Background The 2019 coronavirus disease pandemic (COVID-19) poses an enormous
threat to public health worldwide, and the ensuing management of social isolation has …

Mendelian randomisation uses genetic variation as a natural experiment to investigate the
causal relations between potentially modifiable risk factors and health outcomes in …

Mendelian randomization (MR) is a valuable tool for detecting causal effects by using
genetic variant associations. Opportunities to apply MR are growing rapidly with the …

Mendelian randomization refers to an analytic approach to assess the causality of an
observed association between a modifiable exposure or risk factor and a clinically relevant …

Abstract Background: The number of Mendelian randomization analyses including large
numbers of genetic variants is rapidly increasing. This is due to the proliferation of genome …

Mendelian randomisation (MR) analysis is an important tool to elucidate the causal
relevance of environmental and biological risk factors for disease. However, causal …

The concept of big data, commonly characterized by volume, variety, velocity, and veracity,
goes far beyond the data type and includes the aspects of data analysis, such as hypothesis …