Developmental disruptions of the dorsal striatum in autism spectrum disorder

MM Evans, J Kim, T Abel, T Nickl-Jockschat… - Biological …, 2023 - Elsevier
Autism spectrum disorder (ASD) is an increasingly prevalent neurodevelopmental condition
that is characterized by social and communication deficits as well as patterns of restricted …

Bridging the translational gap: what can synaptopathies tell us about autism?

CJ Molloy, J Cooke, NJF Gatford… - Frontiers in Molecular …, 2023 - frontiersin.org
Multiple molecular pathways and cellular processes have been implicated in the
neurobiology of autism and other neurodevelopmental conditions. There is a current focus …

Group I and group II metabotropic glutamate receptors are upregulated in the synapses of infant rats prenatally exposed to valproic acid

S D'Antoni, S Schiavi, V Buzzelli, S Giuffrida, A Feo… - …, 2023 - Springer
Rationale Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized
by impaired social interaction and restricted/stereotyped behavior. Prenatal exposure to …

[HTML][HTML] Metabotropic glutamate receptors (mGluRs) in epileptogenesis: an update on abnormal mGluRs signaling and its therapeutic implications

L Huang, W Xiao, Y Wang, J Li, J Gong… - Neural Regeneration …, 2024 - journals.lww.com
Epilepsy is a neurological disorder characterized by high morbidity, high recurrence, and
drug resistance. Enhanced signaling through the excitatory neurotransmitter glutamate is …

Glutamate levels of the right and left anterior cingulate cortex in autistics adults

F Briend, L Barantin, H Cléry, JP Cottier… - Progress in Neuro …, 2023 - Elsevier
Abstract Background The neurobiology of Autism Spectrum Disorder (ASD) is still unknown.
Alteration in glutamate metabolism might translate into an imbalance of the …

The 'PSILAUT'protocol: an experimental medicine study of autistic differences in the function of brain serotonin targets of psilocybin

TP Whelan, E Daly, NA Puts, P Smith, C Allison… - BMC psychiatry, 2024 - Springer
Background The underlying neurobiology of the complex autism phenotype remains
obscure, although accumulating evidence implicates the serotonin system and especially …

Metabotropic glutamate receptor genetic variants and peripheral receptor expression affects trait scores of autistic probands

N Dutta, M Chatterjee, S Saha, S Sinha… - Scientific Reports, 2024 - nature.com
Glutamate (Glu) is important for memory and learning. Hence, Glu imbalance is speculated
to affect autism spectrum disorder (ASD) pathophysiology. The action of Glu is mediated …

Analysis of single nucleotide polymorphisms of the metabotropic glutamate receptors in a transgender population

R Fernández, K Ramírez… - Frontiers in …, 2024 - frontiersin.org
Introduction Gender incongruence (GI) is characterized by a marked incongruence between
an individual's experienced/expressed gender and the assigned sex at birth. It includes …

Epigenetic underpinnings of the autistic mind: Histone modifications and prefrontal excitation/inhibition imbalance

YA Fard, EN Sadeghi, Z Pajoohesh… - American Journal of …, 2024 - Wiley Online Library
Autism spectrum disorder (ASD) is complex neurobehavioral condition influenced by several
cellular and molecular mechanisms that are often concerned with synaptogenesis and …

癫痫与代谢型谷氨酸受体: 异常mGluRs 信号转导及其治疗意义的最新进展

L Huang, W Xiao, Y Wang, J Li, J Gong, E Tu… - 中国神经再生研究 …, 2024 - sjzsyj.com.cn
研究表明, 癫痫可能是由体内兴奋性和抑制性神经递质的相对不平衡引起. 其中,
谷氨酸作为哺乳动物中枢神经系统中的重要兴奋性神经递质, 通过激活离子型谷氨酸受体和代谢 …