There has been a steep increase in allergic and autoimmune diseases, reaching epidemic
proportions and now affecting more than one billion people worldwide. These diseases are …

There has been extensive progress in understanding the cellular and molecular
mechanisms of inflammation and immune regulation in allergic diseases of the skin and …

The physiological functions of mast cells remain largely an enigma. In the context of barrier
damage, mast cells are integrated in type 2 immunity and, together with immunoglobulin E …

Food allergy is a major health issue, affecting the lives of 8% of US children and their
families. There is an urgent need to identify the environmental and endogenous signals that …

FcεRI is the primary receptor in mast cells that mediates allergic reactions by inducing rapid
release of mediators, an adaptive immune response that might have evolved as a host …

Immune cell locomotion is associated with amoeboid migration, a flexible mode of
movement, which depends on rapid cycles of actin polymerization and actomyosin …

Mast cells are important components of the immune system, and they perform pro-
inflammatory as well as anti-inflammatory roles in the complex process of immune regulation …

All antibodies approved for cancer therapy are monoclonal IgGs but the biology of IgE,
supported by comparative preclinical data, offers the potential for enhanced effector cell …

The pathophysiological roles of mast cells are still not fully understood, over 140 years since
their description by Paul Ehrlich in 1878. Initial studies have attempted to identify distinct …

Allergen-specific immunoglobulin E (IgE) antibodies mediate pathology in diseases such as
allergic rhinitis and food allergy. Memory B cells (MBCs) contribute to circulating IgE by …