[HTML][HTML] Modeling the tumor microenvironment and cancer immunotherapy in next-generation humanized mice
A Chen, I Neuwirth, D Herndler-Brandstetter - Cancers, 2023 - mdpi.com
Simple Summary A bottleneck in oncology is the translation of results from preclinical
models to the clinics. The rate of anticancer drugs that are effective in preclinical studies but …
models to the clinics. The rate of anticancer drugs that are effective in preclinical studies but …
Mouse Models for Head and Neck Squamous Cell Carcinoma
J Zhou, C Liu, P Amornphimoltham… - Journal of Dental …, 2024 - journals.sagepub.com
The prognosis and survival rate of head and neck squamous cell carcinoma (HNSCC) have
remained unchanged for years, and the pathogenesis of HNSCC is still not fully understood …
remained unchanged for years, and the pathogenesis of HNSCC is still not fully understood …
[HTML][HTML] Fetal liver CD34+ contain human immune and endothelial progenitors and mediate solid tumor rejection in NOG mice
T Celhar, X Li, Y Zhao, HC Tay, A Lee, HH Liew… - Stem Cell Research & …, 2024 - Springer
Background Transplantation of CD34+ hematopoietic stem and progenitor cells (HSPC) into
immunodeficient mice is an established method to generate humanized mice harbouring a …
immunodeficient mice is an established method to generate humanized mice harbouring a …
Primary infection enhances neutrophil-mediated host defense by educating HSPCs
P Wu, Q Zhang, X Xu, S He, Z Liu, Y Li… - International …, 2024 - Elsevier
Hematopoietic stem and progenitor cells (HSPCs) can give rise to all kinds of immune cells
including neutrophils. Neutrophils are the first line of defense in the innate immune system …
including neutrophils. Neutrophils are the first line of defense in the innate immune system …
The Multifaceted Role Of Neutrophil Heterogeneity In Covid-19 Pathogenesis
MD Davis - 2024 - digitalcommons.library.uab.edu
COVID-19 is a respiratory illness caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection. The disease is characterized by an excessive …
coronavirus 2 (SARS-CoV-2) infection. The disease is characterized by an excessive …
Improvement of multilineage hematopoiesis in hematopoietic stem cell-transferred c-kit mutant NOG-EXL humanized mice
R Ito, Y Ohno, Y Mu, Y Ka, S Ito, M Emi-Sugie… - 2023 - researchsquare.com
Human hematopoietic stem cell (HSC)-transferred humanized mice are valuable for
exploring human hematology and immunology. However, sufficient recapitulation of human …
exploring human hematology and immunology. However, sufficient recapitulation of human …