The cumulative science linking stress to negative health outcomes is vast. Stress can affect
health directly, through autonomic and neuroendocrine responses, but also indirectly …

Summary Background Adverse childhood experiences (ACEs) are associated with
increased health risks across the life course. We aimed to estimate the annual health and …

Abstract Background The Center for Disease Control (CDC) and Kaiser Permanente
developed the Adverse Childhood Experiences (ACE) scale to identify negative experiences …

The activation of stress-related neuroendocrine systems helps to maintain homeostasis, but
excessive stress can damage body functions. We review current evidence from basic …

Background An increasing number of studies are identifying associations between adverse
childhood experiences (ACEs) and ill health throughout the life course. We aimed to …

Background A growing body of research identifies the harmful effects that adverse childhood
experiences (ACEs; occurring during childhood or adolescence; eg, child maltreatment or …

Introduction Adverse childhood experiences (ACEs) are associated with early mortality and
morbidity. This study evaluated the association among ACEs, high-risk health behaviors …

Abstract Background Adverse childhood experiences (ACEs) including maltreatment and
exposure to household stressors can impact the health of children. Community factors that …

Background Childhood is a sensitive period with rapid brain development and physiological
growth, and adverse events in childhood might interfere with these processes and have long …

Abstract Background Adverse childhood experiences (ACEs) including child abuse and
household problems (eg domestic violence) increase risks of poor health and mental well …