Heterologous (“nonspecific”) and sex-differential effects of vaccines: epidemiology, clinical trials, and emerging immunologic mechanisms

KL Flanagan, R van Crevel, N Curtis… - Clinical Infectious …, 2013 - academic.oup.com
A growing body of evidence from epidemiologic, clinical, and immunologic studies indicates
that vaccines can influence morbidity and mortality independent of vaccine-specific B-cell or …

Nonspecific effects of vaccines and the reduction of mortality in children

F Shann - Clinical therapeutics, 2013 - Elsevier
There is now strong evidence that vaccines have substantial nonspecific (heterologous)
effects in children in high-mortality regions. The hypothesis states that, until a different …

Child survival and BCG vaccination: a community based prospective cohort study in Uganda

V Nankabirwa, JK Tumwine, PM Mugaba, T Tylleskär… - BMC public health, 2015 - Springer
Background Data on non-specific effects of BCG vaccination in well described, general
population African cohorts is scanty. We report the effects of BCG vaccination on post …

Novel adjuvant formulations for delivery of anti-tuberculosis vaccine candidates

EM Agger - Advanced drug delivery reviews, 2016 - Elsevier
There is an urgent need for a new and improved vaccine against tuberculosis for controlling
this disease that continues to pose a global health threat. The current research strategy is to …

Association between live childhood vaccines and COVID-19 outcomes: a national-level analysis

C Ogimi, P Qu, M Boeckh, RAB Ignacio… - Epidemiology & …, 2021 - cambridge.org
We investigated whether countries with higher coverage of childhood live vaccines [BCG or
measles-containing-vaccine (MCV)] have reduced risk of coronavirus disease 2019 (COVID …

Can earlier BCG-Japan and OPV vaccination reduce early infant mortality? A cluster-randomised trial in Guinea-Bissau

SM Thysen, I da Silva Borges, J Martins… - BMJ Global …, 2024 - gh.bmj.com
Objective To assess the effect of providing BCG and oral polio vaccine (OPV) at an early
home visit after delivery. Design Cluster-randomised trial, randomising 92 geographically …

[HTML][HTML] Neonatal BCG vaccination is associated with enhanced T-helper 1 immune responses to heterologous infant vaccines

DH Libraty, L Zhang, M Woda, LP Acosta… - Trials in …, 2014 - Elsevier
Abstract Neonatal Bacille Calmette Guérin (BCG) vaccination has been reported to have
beneficial effects beyond preventing infantile tuberculous meningitis and miliary disease …

BCG coverage and barriers to BCG vaccination in Guinea-Bissau: an observational study

SM Thysen, S Byberg, M Pedersen, A Rodrigues… - BMC public health, 2014 - Springer
Background BCG vaccination is recommended at birth in low-income countries, but
vaccination is often delayed. Often 20-dose vials of BCG are not opened unless at least ten …

Leveraging beneficial off-target effects of live-attenuated rotavirus vaccines

P Benedicto-Matambo, JE Bines, C Malamba-Banda… - Vaccines, 2022 - mdpi.com
Following the introduction of live-attenuated rotavirus vaccines in many countries, a notable
reduction in deaths and hospitalisations associated with diarrhoea in children< 5 years of …

BCG vaccination and all-cause neonatal mortality

N Curtis - The Pediatric Infectious Disease Journal, 2019 - journals.lww.com
Curtis The Pediatric Infectious Disease Journal• Volume 38, Number 2, February 2019 196|
www. pidj. com© 2019 Wolters Kluwer Health, Inc. All rights reserved. twice the protective …