mRNA nanomedicine: Design and recent applications

LJ Kubiatowicz, A Mohapatra, N Krishnan… - …, 2022 - Wiley Online Library
The rational design and application of mRNA‐based medicine have recently yielded some
key successes in the clinical management of human diseases. mRNA technology allows for …

Principles of nanoparticle formation by flash nanoprecipitation

WS Saad, RK Prud'homme - Nano Today, 2016 - Elsevier
Rapid precipitation is an efficient approach for engineering materials at the nanoscale. By
controlling solute nucleation and growth rates in solvent precipitation processes, the size of …

[HTML][HTML] Hydrophobic ion pairing: encapsulating small molecules, peptides, and proteins into nanocarriers

KD Ristroph, RK Prud'homme - Nanoscale advances, 2019 - pubs.rsc.org
Hydrophobic ion pairing has emerged as a method to modulate the solubility of charged
hydrophilic molecules ranging in class from small molecules to large enzymes. Charged …

Lipid–drug conjugate for enhancing drug delivery

D Irby, C Du, F Li - Molecular pharmaceutics, 2017 - ACS Publications
Lipid–drug conjugates (LDCs) are drug molecules that have been covalently modified with
lipids. The conjugation of lipids to drug molecules increases lipophilicity and also changes …

Review of long-wavelength optical and NIR imaging materials: contrast agents, fluorophores, and multifunctional nano carriers

VJ Pansare, S Hejazi, WJ Faenza… - Chemistry of …, 2012 - ACS Publications
The importance of long wavelength and near-infrared (NIR) imaging has dramatically
increased due to the desire to perform whole animal and deep tissue imaging. The adoption …

Prodrug-based nanoparticulate drug delivery strategies for cancer therapy

C Luo, J Sun, B Sun, Z He - Trends in pharmacological sciences, 2014 - cell.com
Despite the rapid developments in nanotechnology and biomaterials, the efficient delivery of
chemotherapeutic agents is still challenging. Prodrug-based nanoassemblies have many …

Nanoparticle size distribution quantification from transmission electron microscopy (TEM) of ruthenium tetroxide stained polymeric nanoparticles

BK Wilson, RK Prud'homme - Journal of Colloid and Interface Science, 2021 - Elsevier
Abstract Hypothesis Dynamic Light Scattering (DLS) generated particle size distributions
(PSD) of polymer-stabilized nanoparticles are dependent on the optimization parameters …

[HTML][HTML] Paclitaxel nano-delivery systems: a comprehensive review

P Ma, RJ Mumper - Journal of nanomedicine & nanotechnology, 2013 - ncbi.nlm.nih.gov
Paclitaxel is one of the most effective chemotherapeutic drugs ever developed and is active
against a broad range of cancers, such as lung, ovarian, and breast cancers. Due to its low …

Controlling drug nanoparticle formation by rapid precipitation

SM D'Addio, RK Prud'homme - Advanced drug delivery reviews, 2011 - Elsevier
Nanoparticles are a drug delivery platform that can enhance the efficacy of active
pharmaceutical ingredients, including poorly-water soluble compounds, ionic drugs …

[图书][B] Anticancer agents from natural products

GM Cragg, DGI Kingston, DJ Newman - 2005 - taylorfrancis.com
Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …