Mitochondria are well known as organelles responsible for the maintenance of cellular
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …

Central nervous system (CNS) disorders affect as many as 1.5 billion people globally. The
limited delivery of most imaging and therapeutic agents into the brain is a major challenge …

Iron accumulation has been associated with the etiology and progression of multiple
neurodegenerative diseases (NDDs). The exact role of iron in these diseases is not fully …

Therapeutic strategies for neurodegenerative disorders have commonly targeted individual
aspects of the disease pathogenesis to little success. Neurodegenerative diseases …

Dementia, a prevalent condition among older individuals, has profound societal
implications. Extensive research has resulted in no cure for what is perceived as the most …

Alzheimer disease (AD) is the most common neurodegenerative disease, and with no
efficient curative treatment available, its medical, social, and economic burdens are …

Aging is the primary risk factor for most neurodegenerative diseases, including Alzheimer's
disease. Major hallmarks of brain aging include neuroinflammation/immune activation and …

Aging is a significant risk factor for Alzheimer's disease (AD), although the precise
mechanism and molecular basis of AD are not yet fully understood. Epigenetic mechanisms …

As an essential component of our innate immune system, the complement system is
responsible for our defense against pathogens. The complement cascade has complex …

Sex differences are present in brain morphology, sex hormones, aging processes and
immune responses. These differences need to be considered for proper modelling of …