An overview on target-based drug design against kinetoplastid protozoan infections: Human African trypanosomiasis, Chagas disease and leishmaniases

V Kourbeli, E Chontzopoulou, K Moschovou, D Pavlos… - Molecules, 2021 - mdpi.com
The protozoan diseases Human African Trypanosomiasis (HAT), Chagas disease (CD), and
leishmaniases span worldwide and therefore their impact is a universal concern. The …

The drugs of sleeping sickness: their mechanisms of action and resistance, and a brief history

H P. De Koning - Tropical Medicine and Infectious Disease, 2020 - mdpi.com
With the incidence of sleeping sickness in decline and genuine progress being made
towards the WHO goal of eliminating sleeping sickness as a major public health concern …

New global targets for NTDs in the WHO roadmap 2021–2030

A Casulli - PLoS neglected tropical diseases, 2021 - journals.plos.org
The second World Neglected Tropical Diseases (NTDs) Day was celebrated on 30 January
2021. To mark the occasion, the World Health Organization (WHO) launched its roadmap for …

Review on Experimental Treatment Strategies Against Trypanosoma cruzi

AL Mazzeti, P Capelari-Oliveira, MT Bahia… - Journal of …, 2021 - Taylor & Francis
Chagas disease is a neglected tropical disease caused by the protozoan Trypanosoma
cruzi. Currently, only nitroheterocyclic nifurtimox (NFX) and benznidazole (BNZ) are …

In vitro susceptibility of Trypanosoma cruzi discrete typing units (DTUs) to benznidazole: A systematic review and meta-analysis

A Vela, M Coral-Almeida, D Sereno… - PLoS neglected …, 2021 - journals.plos.org
Background Chagas disease, a neglected tropical disease endemic to Latin America
caused by the parasite Trypanosoma cruzi, currently affects 6–7 million people and is …

Review of pharmacological options for the treatment of Chagas disease

F Lascano, F García Bournissen… - British journal of clinical …, 2022 - Wiley Online Library
Chagas disease (CD) is a worldwide problem, with over 8 million people infected in both
rural and urban areas. CD was first described over a century ago, but only two drugs are …

Dual and opposite roles of reactive oxygen species (ROS) in Chagas disease: beneficial on the pathogen and harmful on the host

E Maldonado, DA Rojas, S Morales… - Oxidative Medicine …, 2020 - Wiley Online Library
Chagas disease is a neglected tropical disease, which affects an estimate of 6‐7 million
people worldwide. Chagas disease is caused by Trypanosoma cruzi, which is a eukaryotic …

Incidence and Predictors of Progression to Chagas Cardiomyopathy: Long-Term Follow-Up of Trypanosoma cruzi–Seropositive Individuals

MCP Nunes, LF Buss, JLP Silva, LNA Martins… - Circulation, 2021 - Am Heart Assoc
Background: There are few contemporary cohorts of Trypanosoma cruzi–seropositive
individuals, and the basic clinical epidemiology of Chagas disease is poorly understood …

Of drugs and trypanosomatids: new tools and knowledge to reduce bottlenecks in drug discovery

A Bhattacharya, A Corbeil, RL do Monte-Neto… - Genes, 2020 - mdpi.com
Leishmaniasis (Leishmania species), sleeping sickness (Trypanosoma brucei), and Chagas
disease (Trypanosoma cruzi) are devastating and globally spread diseases caused by …

Screening marine natural products for new drug leads against trypanosomatids and malaria

M Álvarez-Bardón, Y Pérez-Pertejo, C Ordóñez… - Marine Drugs, 2020 - mdpi.com
Neglected Tropical Diseases (NTD) represent a serious threat to humans, especially for
those living in poor or developing countries. Almost one-sixth of the world population is at …