[HTML][HTML] The beneficial mechanism of chitosan and chitooligosaccharides in the intestine on different health status

Y Chen, Z Ling, X Wang, S Zong, J Yang… - Journal of Functional …, 2022 - Elsevier
Chitosan and Chitooligosaccharides can serve as prominent food materials with high
biological activities, of which the intestinal flora regulation is critical to probiotic regulation as …

Targeted polysaccharide nanoparticle for adamplatin prodrug delivery

Y Yang, YM Zhang, Y Chen, JT Chen… - Journal of medicinal …, 2013 - ACS Publications
A series of conjugated hyaluronic acid particles (HAP), composed of a hydrophobic
anticancer drug core and hydrophilic cyclodextrin/hyaluronic acid shell, were prepared …

Amphiphilic quaternary ammonium chitosan/sodium alginate multilayer coatings kill fungal cells and inhibit fungal biofilm on dental biomaterials

J Jung, L Li, CK Yeh, X Ren, Y Sun - Materials Science and Engineering: C, 2019 - Elsevier
Formation of fungal biofilms on health care-related materials causes serious clinical
consequences. This study reports a novel fungal repelling strategy to control fungal biofilm …

Reviewing chitin/chitosan nanofibers and associated nanocomposites and their attained medical milestones

I Sivanesan, J Gopal, M Muthu, J Shin, JW Oh - Polymers, 2021 - mdpi.com
Chitin/chitosan research is an expanding field with wide scope within polymer research. This
topic is highly inviting as chitin/chitosan's are natural biopolymers that can be recovered …

Polymer–covalent organic frameworks composites for glucose and PH dual‐responsive insulin delivery in mice

G Zhang, Y Ji, X Li, X Wang, M Song… - Advanced …, 2020 - Wiley Online Library
Glucose and pH dual‐responsive insulin delivery carriers that have been validated in animal
models, remain elusive and much desired. Herein, a new class of covalent organic …

How the lack of chitosan characterization precludes implementation of the safe-by-design concept

C Marques, C Som, M Schmutz, O Borges… - … in bioengineering and …, 2020 - frontiersin.org
Efficacy and safety of nanomedicines based on polymeric (bio) materials will benefit from a
rational implementation of a Safe-by-Design (SbD) approach throughout their development …

[HTML][HTML] Charge-switchable zwitterionic polycarboxybetaine particle as an intestinal permeation enhancer for efficient oral insulin delivery

Y Li, W Ji, H Peng, R Zhao, T Zhang, Z Lu, J Yang… - Theranostics, 2021 - ncbi.nlm.nih.gov
Insulin, a peptide hormone, is one of the most common and effective antidiabetic drugs.
Although oral administration is considered to be the most convenient and safe choice for …

Investigating the role of Pluronic-g-Cationic polyelectrolyte as functional stabilizer for nanocrystals: Impact on Paclitaxel oral bioavailability and tumor growth

S Sharma, A Verma, G Pandey, N Mittapelly… - Acta Biomaterialia, 2015 - Elsevier
Paclitaxel (PTX) is a potent anticancer drug which suffers limitations of extremely low oral
bioavailability due to low solubility, rapid metabolism and efflux by P-gp transporters. The …

Novel amphiphilic chitosan nanocarriers for sustained oral delivery of hydrophobic drugs

M Motiei, S Kashanian - European journal of pharmaceutical sciences, 2017 - Elsevier
Chitosan (CS) has been investigated for its ability to be modified hydrophobically and self-
assembled into nanocarriers. They can encapsulate drugs and protect them in a promising …

Intestinal absorption of insulin nanoparticles: contribution of M cells

MA Lopes, BA Abrahim, LM Cabral… - … , Biology and Medicine, 2014 - Elsevier
Nanodelivery systems have been extensively studied as a strategy for the effective treatment
of type 1 diabetes in animal models. Nanoparticle formulations have been shown to …