Approximately 6% of adults worldwide have atherosclerosis and thrombosis of the lower
limb arteries (peripheral artery disease (PAD)) and the prevalence is rising. PAD causes leg …

Chronic wound management represents a major challenge in the healthcare sector owing to
its delayed wound-healing process progression and huge financial burden. In this regard …

A wound is considered hard-to-heal when, despite the appropriate clinical analysis and
intervention, the wound area reduces by less than a third at four weeks and complete …

Objectives Homocysteine (Hcy) level has been widely identified as a risk factor associated
with adverse outcomes in patients with lower extremity atherosclerotic disease (LEAD) …

With the high incidence of diabetes around the world, ischemic complications cause a
serious influence on people's production and living. Neovascularization plays a significant …

体表慢性难愈合创面的诊断和治疗一直充满着挑战, 对医疗和社会造成巨大负担.
利用高通量测序技术结合组学分析可以揭示慢性创面形成的潜在机制, 识别与慢性创面诊断 …

Background Peripheral artery disease is characterized by an intense inflammatory process
that can be associated with a higher mortality rate, particularly in chronic limb‐threatening …

Cardiovascular (CVD) and cerebrovascular diseases, with 17.9 million and 2 million deaths
every year, respectively, are the leading cause of death worldwide [1, 2]. The accumulation …

Phenotype switching of vascular smooth muscle cells (VSMCs) is a pathological process in
various vascular diseases. Canopy FGF signaling regulator 2 (CNPY2) has previously been …

Ethnopharmacological relevance Shuxuetong (SXT) injection is formulated by leech and
earthworm, has been widely used in the treatment of thrombotic cardiovascular and …