Pharmacologic and toxic effects of xenobiotics, such as drugs of abuse, depend on the
genotype and phenotype of an individual, and conversely on the isoenzymes involved in …

Metabolic profiling of cancer cells has recently been established as a promising tool for the
development of therapies and identification of cancer biomarkers. Here we characterized the …

GABA is assumed to function in brain only as an inhibitory neurotransmitter. Here we report
a much broader CNS role. We show that human astrocytes are GABAergic cells, and that …

Abstract γ‐Hydroxybutyrate (GHB) is both a natural brain compound with neuromodulatory
properties at central GABAergic synapses (micromolar concentration range) and also a drug …

Metabolic network rewiring is the rerouting of metabolism through the use of alternate
enzymes to adjust pathway flux and accomplish specific anabolic or catabolic objectives …

Metabolic reprogramming in breast tumors is linked to increases in putative oncogenic
metabolites that may contribute to malignant transformation. We previously showed that …

l-Serine biosynthesis, a crucial metabolic process in most domains of life, is initiated by d-3-
phosphoglycerate (d-3-PG) dehydrogenation, a thermodynamically unfavorable reaction …

Alcohol dehydrogenases (ADH), encoded by multigene family in plants, play a critical role in
plant growth, development, adaptation, fruit ripening and aroma production. Thirteen ADH …

A reduction in cerebral glucose utilization is one of the earliest signs of Alzheimer's disease.
Although the exact cause of this reduction is not known, gathering evidence suggests that it …

Background Selection for exercise-adapted phenotypes in the Thoroughbred racehorse has
provided a valuable model system to understand molecular responses to exercise in …