Neutrophils or polymorphonuclear leukocytes (PMN) are key participants in the innate
immune response for their ability to execute different effector functions. These cells express …

The engulfment of apoptotic cells by phagocytes, a process referred to as efferocytosis, is
essential for maintenance of normal tissue homeostasis and a prerequisite for the resolution …

Influenza infection increases the incidence of myocardial infarction but the reason is
unknown. Platelets mediate vascular occlusion through thrombotic functions but are also …

Sepsis remains a leading cause of death worldwide, despite advances in critical care, and
understanding of the pathophysiology and treatment strategies. No specific therapy or drugs …

The heme protein myeloperoxidase (MPO) is a major constituent of neutrophils. As a key
mediator of the innate immune system, neutrophils are rapidly recruited to inflammatory …

Neutrophil extracellular traps (NETs) represent extracellular structures able to bind and kill
microorganisms. It is believed that they are generated by neutrophils undergoing cell death …

Granulocytes, the most abundant types of leukocytes, are the first line of defense against
pathogen invasion. However, the plasticity and diversity of granulocytes have been …

Abstract Autophagy-related gene (Atg) 5 is a gene product required for the formation of
autophagosomes. Here, we report that Atg5, in addition to the promotion of autophagy …

The production and deployment of phagocytes are central functions of the hematopoietic
system. In the 1950s, radioisotopic studies demonstrated the high prodution rate and short …

Human health is under constant threat of a wide variety of dangers, both self and nonself.
The immune system is occupied with protecting the host against such dangers in order to …