Inherited diseases caused by connexin mutations are found in multiple organs and include
hereditary deafness, congenital cataract, congenital heart diseases, hereditary skin …

Gap junction-mediated intercellular communication facilitates the circulation of ions, small
molecules, and metabolites in the avascular eye lens. Mutants of the lens fiber cell gap …

The lens is an avascular organ composed of an anterior epithelial cell layer and fiber cells
that form the bulk of the organ. The lens expresses connexin43 (Cx43), connexin46 (Cx46) …

Collaborative communication lies at the centre of multicellular life. Gap junctions (GJs) are
surface membrane structures that allow direct communication between cells. They were …

The lens is an avascular organ that is supported by an internal circulation of water and
solutes. This circulation is driven by ion pumps, channels and transporters in epithelial cells …

The lens is continuously exposed to oxidative stress insults, such as ultraviolet radiation and
other oxidative factors, during the aging process. The lens possesses powerful oxidative …

Cataract is a common disease in the aging population. Gap junction has been considered a
central component in maintaining homeostasis for preventing cataract formation. Gap …

Runs of homozygosity (ROH) and heterozygosity (ROHet) are windows into population
demographic history and adaptive evolution. Numerous studies have shown that deleterious …

The lens is an avascular organ whose function and survival depend on an internal
circulation system. Cx46fs380 mice model a human autosomal dominant cataract caused by …

Cataracts are lens opacities that are among the most common causes of blindness. It is
commonly believed that cataracts develop through the accumulation of damage to lens …