[HTML][HTML] An updated review summarizing the anticancer efficacy of melittin from bee venom in several models of human cancers

P Pandey, F Khan, MA Khan, R Kumar, TK Upadhyay - Nutrients, 2023 - mdpi.com
Apitherapy (using bee products) has gained broad recognition in cancer therapeutics
globally. Honeybee venom has a broad range of biological potential, and its utilization is …

[HTML][HTML] Beyond lipid-lowering: effects of statins on cardiovascular and cerebrovascular diseases and cancer

Y Morofuji, S Nakagawa, K Ujifuku, T Fujimoto… - Pharmaceuticals, 2022 - mdpi.com
The 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, also known
as statins, are administered as first-line therapy for hypercholesterolemia, both as primary …

[HTML][HTML] Peptide-based bioconjugates and therapeutics for targeted anticancer therapy

SB Yang, N Banik, B Han, DN Lee, J Park - Pharmaceutics, 2022 - mdpi.com
With rapidly growing knowledge in bioinformatics related to peptides and proteins, amino
acid-based drug-design strategies have recently gained importance in pharmaceutics. In the …

[HTML][HTML] The role of the BH4 cofactor in nitric oxide synthase activity and cancer progression: two sides of the same coin

DA Gonçalves, MG Jasiulionis, FHM Melo - International journal of …, 2021 - mdpi.com
Cancer development is associated with abnormal proliferation, genetic instability, cell death
resistance, metabolic reprogramming, immunity evasion, and metastasis. These alterations …

[HTML][HTML] Ceftriaxone and melittin synergistically promote wound healing in diabetic rats

NA Alhakamy, G Caruso, BG Eid, UA Fahmy… - Pharmaceutics, 2021 - mdpi.com
High glucose levels in diabetic patients are implicated in delay wound healing that could
lead to more serious clinical complications. The aim of the present work was to examine the …

Regulating Cholesterol in Tumorigenesis: A Novel Paradigm for Tumor Nanotherapeutics

H Wu, X Wu, M Zhao, J Yan, C Li, Z Zhang… - International Journal …, 2024 - Taylor & Francis
During the past decade,“membrane lipid therapy”, which involves the regulation of the
structure and function of tumor cell plasma membranes, has emerged as a new strategy for …

[HTML][HTML] Hybrid nanoparticulate system of Fluvastatin loaded phospholipid, alpha lipoic acid and melittin for the management of colon cancer

MA Alfaleh, O Fahmy, MW Al-Rabia… - Scientific Reports, 2022 - nature.com
As a hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, Fluvastatin (FLV) is
used for reducing low-density lipoprotein (LDL) cholesterol as well as to prevent …

[HTML][HTML] Piceatannol-loaded bilosome-stabilized zein protein exhibits enhanced cytostatic and apoptotic activities in lung cancer cells

NA Alhakamy, G Caruso, MW Al-Rabia, SM Badr-Eldin… - Pharmaceutics, 2021 - mdpi.com
Piceatannol (PIC) is a naturally occurring polyphenolic stilbene, and it has pleiotropic
pharmacological properties. Moreover, PIC has cytotoxic actions among various cancer …

Optimized 2-methoxyestradiol invasomes fortified with apamin: A promising approach for suppression of A549 lung cancer cells

ZA Awan, SA AlGhamdi, NA Alhakamy… - Drug Delivery, 2022 - Taylor & Francis
Certain anticancer agents selectively target the nucleus of cancer cells. One such drug is 2-
methoxyestradiol (2ME), which is used for treating lung cancer. To improve the therapeutic …

[HTML][HTML] SiO2–alginate–melittin nano-conjugates suppress the proliferation of ovarian cancer cells: a controlled release approach leveraging alginate lyase

L Si, S Yang, R Lin, S Gu, C Yan, J Yan - Cancer Nanotechnology, 2024 - Springer
Background Ovarian cancer treatment is challenged by resistance and off-target effects.
Melittin shows promise against cancer but is limited by its instability and harmful cellular …